Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
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DOI：
10.1001/archneur.60.3.337
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发表时间：
2003-03-01
影响因子：
--
通讯作者：
Chui, HC
中科院分区：
文献类型：
--
作者：
Zarow, C;Lyness, SA;Chui, HC
内容：阿尔茨海默病（Alzheimer disease，AD）和帕金森病（Parkinson disease，PD）与皮质下主要核团的神经元变性有关，但同时研究这些核团神经元变性的研究较少。目的：探讨AD和PD患者基底核（nucleus basalis，NB）、蓝斑（locus coeruleus，LC）和黑质（substantia nigra pars rectata，SN）神经元变性的临床和病理相关性。研究样本包括86例病理证实的AD患者，19例PD患者和13例健康老年对照受试者。在NB、LC和SN的代表性切片中计数核仁化神经元的数量。结果：AD患者LC区神经元丢失率最高（ES=3.16），其次为NB区（ES=1.10），SN区神经元丢失率最高（ES=0.16）。PD病例中LC的神经元丢失最多（ES=6：47），其次是SN（ES=2.58）和NB（ES=0.85）。PD组NB与LC神经元数目呈显著正相关（r= 0.54，P
Context: Alzheimer disease (AD) and Parkinson disease (PD) are associated with neuronal degeneration in major subcortical nuclei, but few studies have examined the neuronal degeneration in these nuclei concurrently.Objective: To identify clinical and pathological correlates of neuronal loss in the nucleus basalis (NB), locus coeruleus (LC), and substantia nigra pars compacta (SN) in AD and PD.Design: The study sample comprised 86 cases with pathologically confirmed AD, 19 cases with PD, and 13 healthy elderly control subjects. The number of nucleolated neurons was counted in representative sections of the NB, LC, and SN. Effect sizes, (ES) were computed to determine the standardized difference in cell counts relative to healthy controls.Results: Cases of AD showed the greatest neuronal loss in the LC (ES=3.16) followed by the NB (ES=1.10), but variable loss in the SN (ES=0.16). Cases of PD also showed the greatest neuronal loss in the LC (ES=6:47), followed by the SN (ES=2.58) and the NB (ES=0.85). Significant correlations were found between the number of neurons in the NB and LC in PD (r=0.54, P