Identification of a Higher-Order Organozincate Intermediate Involved in Negishi Cross-Coupling Reactions by Mass Spectrometry and NMR Spectroscopy
Identification of a Higher-Order Organozincate Intermediate Involved in Negishi Cross-Coupling Reactions by Mass Spectrometry and NMR Spectroscopy
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DOI：
10.1002/chem.201101029
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发表时间：
2011-07-01
影响因子：
4.3
通讯作者：
Organ, Michael G.
中科院分区：
文献类型：
--
作者：
Hunter, Howard N.;Hadei, Niloufar;Organ, Michael G.
在溶液中通过质谱和NMR光谱分析Negishi交叉偶联反应，以鉴定LiBr作为添加剂的效果以及3-二甲基-2-咪唑啉酮（3-dimethyl-2-imidazolinone，简称DMI-M）作为共溶剂的目的。结果表明，在添加LiBr的过程中，溴代锌的主要作用是促进更高级的溴代锌酸盐的形成。
Negishi cross-coupling reactions were analyzed in solution by mass spectrometry and NMR spectroscopy to identify both the effect of LiBr as an additive as well as the purpose of 3-dimethyl-2-imidazolidinone (DMI) as a co-solvent. The results suggest that the main role of DMI is to facilitate a higher order bromo-zincate formation during the addition of LiBr.