Recombinant organisms for production of industrial products.
Recombinant organisms for production of industrial products.
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DOI：
10.4161/bbug.1.2.10484
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发表时间：
2010-03-01
期刊：
影响因子：
--
通讯作者：
Demain, Arnold L
中科院分区：
文献类型：
--
作者：
Adrio, Jose-Luis;Demain, Arnold L
DNA双链结构的发现和重组DNA技术的发展引发了工业微生物学的一场革命。传统的工业微生物学与分子生物学相结合，产生了用于初级和次级代谢产物、蛋白质生物制药和工业酶的工业生产的改进的重组过程。新的遗传技术，如代谢工程，组合生物合成和分子育种技术及其修改，大大有助于改进工业过程的发展。此外，功能基因组学、蛋白质组学和代谢组学正被用于发现新的有价值的医药小分子以及用于催化的酶。正在进行工业微生物基因组测序，这对未来的工艺改进和新工业产品的发现是个好兆头。
A revolution in industrial microbiology was sparked by the discoveries of ther double-stranded structure of DNA and the development of recombinant DNA technology. Traditional industrial microbiology was merged with molecular biology to yield improved recombinant processes for the industrial production of primary and secondary metabolites, protein biopharmaceuticals and industrial enzymes. Novel genetic techniques such as metabolic engineering, combinatorial biosynthesis and molecular breeding techniques and their modifications are contributing greatly to the development of improved industrial processes. In addition, functional genomics, proteomics and metabolomics are being exploited for the discovery of novel valuable small molecules for medicine as well as enzymes for catalysis. The sequencing of industrial microbal genomes is being carried out which bodes well for future process improvement and discovery of new industrial products.