Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls:: a bioconversion defect can be suspected
Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls:: a bioconversion defect can be suspected
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DOI：
10.1038/sj.ejcn.1600792
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发表时间：
1999-08-01
影响因子：
4.7
通讯作者：
Descomps, B
中科院分区：
文献类型：
--
作者：
Babin, F;Abderrazik, M;Descomps, B
目的：评估非机构化老年妇女的多不饱和脂肪酸（PUFA）状况，并检测可能的必需脂肪酸生物转化缺陷。 设计和受试者：采用毛细管柱气相色谱法测定 200 名 75 岁以上非机构化健康老年妇女样本中总血浆脂、血浆甘油三酯（TG）、胆固醇酯（CE）、磷脂（PL）和红细胞的脂肪酸组成。将数据与由 50 名 20-48 岁年轻女性志愿者组成的对照组进行比较。结果：在老年女性中，n-6 系列前体亚油酸（18:2 n-6）的 TG 和 CE 较低（分别为 P = 0.029 和 0.014）。在 CE 中，这种脂肪酸与蔬菜和蔬菜摄入量高度相关 (P < 0.0001)，表明膳食供应量低于对照组。在老年女性的所有血浆脂质组分中发现 16:1 n-7 的百分比较高，特别是在 CE 中 (P < 0.0001)。老年女性 PL 中 20:4 n-6/20:3 n-6 和 22.6 n-3/20:5 n-3 的比率显着较低（分别为 P < 0.005 和 P < 0.002），这提出了 20:1 n-6 和 22:6 n-3 生物合成最终步骤的效率问题。对老年妇女的膳食调查表明，通过肉类摄入的高膳食蛋白质可能有助于 20:4 n-6 的供应，从而维持了这种脂肪酸的状态，尽管生物合成被怀疑发生了改变。结论：老年妇女中的 PUFA 状态可能比之前怀疑的更脆弱，并且更依赖于长链 PUFA 的外源供应。
Objective: To evaluate the polyunsaturated fatty acid (PUFA) status in non institutionalised elderly women and to detect a possible essential fatty acid bioconversion defect.Design and subjects: The fatty acid composition of total plasma lipids, plasma triglycerides (TG), cholesterol esters (CE), phospholipids (PL), and erythrocytes was determined by capillary column gas-liquid chromatography in a sample of 200 non-institutionalised healthy elderly women over 75 years of age. The data were compared with those of a control group of 50 young female volunteers aged 20-48 y.Results: In elderly women, the n-6 series precursor, linoleic acid(18:2 n-6), was lower in TG and CE (P = 0.029 and 0.014, respectively). In CE, this fatty acid was highly correlated with vegetable and vegetal far intakes (P < 0.0001), suggesting a lower dietary supply than in controls, Higher percentages of 16:1 n-7 were found in all the plasma lipid fractions in elderly women, especially in CE (P < 0.0001). The ratios 20:4 n-6/20:3 n-6 and 22.6 n-3/20:5 n-3 were significantly lower in PL from elderly women (P < 0.005 and P < 0.002, respectively), raising the question of the efficiency of the terminal steps of 20:I n-6 and 22:6 n-3 biosynthesis. Dietary investigations in elderly women indicated that a high dietary protein intake via meat probably contributed to the supply of 20:4 n-6 and thus maintained the status of this fatty acid, despite the suspected altered biosynthesis.Conclusion: The PUFA status in the elderly women group could be more fragile and dependent on exogenous supply of long-chain PUFAs than previously suspected.