The role of adaptation in generating monotonic rate codes in auditory cortex
The role of adaptation in generating monotonic rate codes in auditory cortex
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DOI：
10.1371/journal.pcbi.1007627
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发表时间：
2019-06
影响因子：
4.3
通讯作者：
Jong Hoon Lee;Xiaoqin Wang;D. Bendor
中科院分区：
文献类型：
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作者：
Jong Hoon Lee;Xiaoqin Wang;D. Bendor
在初级听觉皮层，缓慢重复的声事件在时间上由单个神经元的锁相活动表示。在清醒的绒猴（Callithrix jacchus）的单单位研究表明，这些神经元的亚群也单调增加或减少其平均放电率在刺激呈现较高的重复率。建立在一个计算单神经元模型，产生锁相响应与刺激诱发的兴奋，然后强烈的抑制，我们发现，刺激诱发的短期抑郁症是足以产生同步单调的积极和消极的反应，缓慢重复的刺激。通过探索模型的鲁棒性，并将其与其他适应此类刺激的模型进行比较，我们得出结论，短期抑郁最好地解释了我们在清醒的绒猴单单位记录中的观察结果。使用该模型，我们模拟了单个神经元如何通过给定刺激特征的单调正编码和负编码来编码和解码声学刺激的多个方面。总之，我们的研究结果表明，一个简单的生物物理机制在单个神经元可以允许一个更复杂的编码和解码的声音刺激。
In primary auditory cortex, slowly repeated acoustic events are represented temporally by phase-locked activity of single neurons. Single-unit studies in awake marmosets (Callithrix jacchus) have shown that a sub-population of these neurons also monotonically increase or decrease their average discharge rate during stimulus presentation for higher repetition rates. Building on a computational single-neuron model that generates phase-locked responses with stimulus evoked excitation followed by strong inhibition, we find that stimulus-evoked short-term depression is sufficient to produce synchronized monotonic positive and negative responses to slowly repeated stimuli. By exploring model robustness and comparing it to other models for adaptation to such stimuli, we conclude that short-term depression best explains our observations in single-unit recordings in awake marmosets. Using this model, we emulated how single neurons could encode and decode multiple aspects of an acoustic stimuli with the monotonic positive and negative encoding of a given stimulus feature. Together, our results show that a simple biophysical mechanism in single neurons can allow a more complex encoding and decoding of acoustic stimuli.