Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat
Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat
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DOI：
10.1242/dev.047126
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发表时间：
2010-10-15
期刊：
影响因子：
4.6
通讯作者：
Lawrence, Peter A.
中科院分区：
文献类型：
--
作者：
Repiso, Ada;Saavedra, Pedro;Lawrence, Peter A.
果蝇的幼虫腹侧带由六到七行有方向的小齿组成，一些指向前方，一些指向后方。我们提出的证据表明，小齿的取向几乎完全由两个平面细胞极性系统之一的Dachsous和Fat决定。如果我们改变Dachsous的分布，我们可以改变齿的极性。我们认为，在前房室（大多数指向后）和后房室（指向前），单个小齿列的方向是由Dachsous/Fat梯度的相反斜率决定的。我们发现，通过改变发育过程中Dachsous的浓度梯度，我们可以改变幼虫细胞在没有有丝分裂的情况下在第一和第三幼虫之间发育的小齿的极性。
The larval ventral belts of Drosophila consist of six to seven rows of denticles that are oriented, some pointing forwards, some backwards. We present evidence that denticle orientation is determined almost entirely by Dachsous and Fat, one of two planar cell polarity systems. If we change the distribution of Dachsous we can alter the polarity of denticles. We suggest that the orientation of the individual denticle rows, in both the anterior compartment (which mostly point backwards) and the posterior compartment (which point forwards), is determined by the opposing slopes of a Dachsous/Fat gradient. We show, by altering the concentration gradients of Dachsous during development, that we can change the polarity of the denticles made by larval cells as they progress between the first and third larval instars without mitosis.