Neuronal activation induced BOLD and CBF responses upon acetazolamide administration in patients with steno-occlusive artery disease.
Neuronal activation induced BOLD and CBF responses upon acetazolamide administration in patients with steno-occlusive artery disease.
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DOI：
10.1016/j.neuroimage.2014.09.033
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发表时间：
2015-01-15
期刊：
影响因子：
5.7
通讯作者：
Hendrikse J
中科院分区：
文献类型：
--
作者：
Siero JC;Hartkamp NS;Donahue MJ;Harteveld AA;Compter A;Petersen ET;Hendrikse J
Blood-oxygenation-level-dependent (BOLD) MRI is widely used for inferring neuronal activation and is becoming increasingly popular for assessing cerebrovascular reactivity (CVR) when combined with a vasoactive stimulus. The BOLD signal contains changes in cerebral blood flow (CBF) and thus information regarding neurovascular coupling and CVR. The BOLD signal, however, is also modulated by changes in cerebral blood volume (CBV) and cerebral metabolic rate of oxygen (CMRO2), as well as changes in the physiological baseline state. Here, we measured BOLD and CBF responses upon neuronal (visual) activation, before and after a vasodilatory challenge (acetazolamide, ACZ) in patients with vertebrobasilar steno-occlusive disease. After ACZ, the neuronal activation induced BOLD response was reduced or even negative (3 out of 8 subjects), whereas the CBF response remained similar. We show that BOLD alone cannot correctly assess the neuronal activation and underlying neurovascular coupling. The generally assumed positive relationship between BOLD and CBF responses may be severely compromised under changes in the physiological baseline state. Accompanying CBF measurements contain crucial information, and simulations suggest an altered flow–metabolism coupling in these patients.
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影响因子：
19.7
作者：
Bokkers, Reinoud P. H.;van Osch, Matthias J. P.;Hendrikse, Jeroen
通讯作者：
Hendrikse, Jeroen
DOI：
10.1073/pnas.0909711107
发表时间：
2010-05-04
影响因子：
11.1
作者：
Lin, Ai-Ling;Fox, Peter T.;Gao, Jia-Hong
通讯作者：
Gao, Jia-Hong
影响因子：
5.7
作者：
Obata, T;Liu, TT;Buxton, RB
通讯作者：
Buxton, RB
影响因子：
3.3
作者：
Lawrence, KSS;Wang, J
通讯作者：
Wang, J
影响因子：
8.3
作者：
Murata, Yoshihiro;Sakatani, Kaoru;Katayama, Yoichi
通讯作者：
Katayama, Yoichi