Hyperpolarized Xe 129 Ventilation Imaging using an Optimized 3 D Steady-state Free-precession Pulse Sequence
Hyperpolarized Xe 129 Ventilation Imaging using an Optimized 3 D Steady-state Free-precession Pulse Sequence
复制标题
使用优化的 3D 稳态自由进动脉冲序列的超极化 Xe 129 通气成像
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
I. Dregely
中科院分区：
文献类型：
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作者：
J. Mugler;T. Altes;I. Ruset;S. Ketel;J. Distelbrink;Y. Chang;J. Mata;F. Hersman;K. Ruppert;I. Dregely
前言：使用超极化气体(HPG)的MRI提供了有关肺的独特的功能和结构信息。然而，人类最常用的试剂HE3在世界范围内供应有限，因此，如果HPG-MRI要广泛应用于临床，很可能需要替代药物Xe129。Xe129的溶解性和化学位移特性允许进行溶解相测量，这是HE3无法实现的。尽管如此，即使考虑到Xe129的这一潜在优势，使用Xe129进行气体空间测量也是非常必要的，因为Xe129是人类使用HE3(例如通风、ADC、动态、PO2)进行测量的先驱，其质量与使用HE3演示的质量相似。为了实现这一目标，有必要利用每一个机会来提高信噪比，因为Xe129的旋磁比大约比HE3的小3倍。最近用HE3证明了优化的3D稳态自由进动(SSFP)脉冲序列可以产生比广泛使用的低翻转角破坏GRE方法高3-4倍的信噪比[1-3]。在这项工作中，我们探索了Xe129使用3D SSFP进行通风成像的潜力。
Introduction: MRI using hyperpolarized gases (HPG) provides unique functional and structural information about the lung. However, the agent that has been most commonly used in humans, He3, is in limited world supply and thus, if widespread clinical application of HPG-MRI is to occur, it likely will require the alternative agent, Xe129. The solubility and chemical-shift characteristics of Xe129 permit dissolved-phase measurements that are not possible with He3. Nonetheless, even considering this potential advantage of Xe129, it would be very desirable to perform gas-space measurements with Xe129, which were pioneered in humans using He3 (e.g., ventilation, ADC, dynamic, pO2), with quality similar to that demonstrated by using He3. To achieve this goal, it is necessary to take advantage of every opportunity to increase the SNR, since the gyromagnetic ratio for Xe129 is about 3 times smaller than that for He3. It was recently demonstrated with He3 that an optimized, 3D steady-state free-precession (SSFP) pulse sequence can yield 3-4 times higher SNR than widely-used low-flip-angle spoiled-GRE methods [1-3]. In this work, we explored the potential of using 3D SSFP for ventilation imaging with Xe129.