Genetic analysis of IREB2, FAM13A and XRCC5 variants in Chinese Han patients with chronic obstructive pulmonary disease
Genetic analysis of IREB2, FAM13A and XRCC5 variants in Chinese Han patients with chronic obstructive pulmonary disease
复制标题
中国汉族慢性阻塞性肺疾病患者IREB2、FAM13A和XRCC5变异基因分析
DOI：
10.1016/j.bbrc.2011.10.042
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发表时间：
2011-11-18
影响因子：
3.1
通讯作者：
Deng, Hao
中科院分区：
文献类型：
--
作者：
Guo, Yi;Lin, Hua;Deng, Hao
最近，变种通过全基因组关联研究（GWAS）发现IREB 2、FAM 13 A和XRCC 5基因中的3个突变（rs 2568494、rs 2869967和rs3821104）与非亚洲人群慢性阻塞性肺疾病（COPD）相关。我们调查了来自中国大陆的中国汉族COPD患者。在基因型分布（rs 2869967的chi（2）= 6.319，p = 0.042; rs3821104的chi（2）= 6.062，p = 0.048）和等位基因分布（rs 2869967的chi（2）= 4.014，p = 0.045;对于变异体rs 2869967和rs3821104，在患者和对照受试者之间观察到χ（2）= 5.607，p = 0.018），而在IREB 2 rs 2568494和COPD表型之间没有鉴定到基因型和等位基因分布的统计学显著关联（p > 0.05）。我们的研究结果支持FAM 13 A rs 2869967和XRCC 5 rs3821104与中国汉族人群COPD相关。(C)2011 Elsevier Inc. All rights reserved.
Recently, variants (rs2568494, rs2869967 and rs3821104) in the IREB2, FAM13A and XRCC5 genes were found to be associated with chronic obstructive pulmonary disease (COPD) in non-Asian populations by genome-wide association study (GWAS) analysis, To evaluate whether variants in these genes are related to COPD in Chinese Han population, we investigated COPD patients of Chinese Han ethnicity from Mainland China. Significant differences in genotypic distributions (chi(2)= 6.319, p = 0.042 for rs2869967; chi(2) = 6.062, p = 0.048 for rs3821104) and allele distributions (chi(2) = 4.014, p = 0.045 for rs2869967; chi(2) = 5.607, p = 0.018 for rs3821104) were observed between patients and control subjects for variants rs2869967 and rs3821104, whereas no statistically significant associations for genotypic and allelic distribution between IREB2 rs2568494 and COPD phenotype (p > 0.05) were identified. Our results support that FAM13A rs2869967 and XRCC5 rs3821104 are associated with COPD in Chinese Han population. (C) 2011 Elsevier Inc. All rights reserved.