System for simultaneously monitoring heart and breathing rate in mice using a piezoelectric transducer
System for simultaneously monitoring heart and breathing rate in mice using a piezoelectric transducer
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DOI：
10.1007/s11517-006-0047-z
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发表时间：
2006-05-01
影响因子：
3.2
通讯作者：
Inagaki, Nobuya
中科院分区：
文献类型：
--
作者：
Sato, Shinichi;Yamada, Katsuya;Inagaki, Nobuya
我们提出了一种新的系统，同时监测心率（HR）和呼吸率（BR）的麻醉小鼠使用压电传感器（PZT）放置在身体下。众所周知，将机械振动转换为电信号的PZT可以检测心音和呼吸运动。然而，没有PZT系统被报道用于同时和连续监测HR和BR，这可能是由于难以消除由心音和呼吸运动的幅度波动引起的噪声和误差。通过定制设计的模拟电路和微处理器程序克服了这些困难，从而与从ECG和传统气流传感器获得的值相比，以高可靠性检测HR和BR。我们相信，这个实用和易于使用的系统可以应用到各种各样的基础和临床研究领域。
We propose a novel system for simultaneously monitoring the heart rate (HR) and breathing rate (BR) of anesthetized mice using a piezoelectric transducer (PZT) placed under the body. It is known that a PZT, which transforms mechanical vibrations into electrical signals, can detect heart sounds and breathing movements. However, no PZT system has been reported for simultaneous and continuous monitoring of HR and BR, possibly due to difficulties in eliminating noises and errors caused by the amplitude fluctuation of heart sounds and breathing movements. These difficulties were overcome by custom-designed analogue circuitry and a microprocessor program, resulting in detection of HR and BR with a high reliability compared to the values obtained from ECG and a conventional airflow sensor. We believe that this practical and easy-to-use system can be applied to a wide variety of basic and clinical research fields.