Distributions, associations, and partial aggregate exposure of pesticides and polynuclear aromatic hydrocarbons in the Minnesota Children's Pesticide Exposure Study (MNCPES)
Distributions, associations, and partial aggregate exposure of pesticides and polynuclear aromatic hydrocarbons in the Minnesota Children's Pesticide Exposure Study (MNCPES)
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DOI：
10.1038/sj.jea.7500261
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发表时间：
2003-03-01
期刊：
影响因子：
--
通讯作者：
Sefton, K
中科院分区：
文献类型：
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作者：
Clayton, CA;Pellizzari, ED;Sefton, K
明尼苏达州儿童农药接触研究 (MNCPES) 提供了与儿童多途径接触四种主要农药（毒死蜱、马拉硫磷、二嗪农和莠去津）、14 种次要农药和 13 种多环芳烃 (PAH) 的接触、环境和生物数据。对明尼阿波利斯/圣路易斯 102 名 3-12 岁儿童的概率样本进行了监测。保罗和附近的农村地区（古德休县和赖斯县）。本文提供了该人群暴露量的估计分布和与暴露相关的测量值，并通过等级（斯皮尔曼）相关性检查了各种测量值之间的关联。此外，它还提供了一些农药的总体和累积暴露估计值，并比较了吸入和膳食摄入的相对摄入量。四种主要农药的摄入量似乎主要来自摄入途径，而不是吸入途径；对于毒死蜱来说，情况显然如此，但对于其他三种主要农药则不太确定，因为它们的漏检率较高。固体食物而不是饮料显然是摄入量的主要贡献者。尽管摄入途径占主导地位，毒死蜱的尿液代谢物与空气测量值的相关性比与饮食测量值的相关性更强。个人空气样本中毒死蜱、马拉硫磷和二嗪磷与室内空气样本表现出很强的等级相关性（分别为 0.81、0.51 和 0.62），而个人空气中莠去津水平与室外水平相关性良好（0.69）；个人空气中二嗪农水平也与室外水平密切相关（0.67）。对于多环芳烃，各种空气样品以及空气样品与灰尘样品之间存在明显的许多显着关联，特别是对于那些具有持续高百分比可测量值的化合物（特别是荧蒽、菲和芘）。
The Minnesota Children's Pesticide Exposure Study (MNCPES) provides exposure, environmental, and biologic data relating to multipathway exposures of children for four primary pesticides (chlorpyrifos, malathion, diazinon, and atrazine), 14 secondary pesticides, and 13 polynuclear aromatic hydrocarbons (PAHs). Monitoring was performed on a probability-based sample of 102 children aged 3-12 in Minneapolis/St. Paul and in a nearby rural area (Goodhue and Rice counties). This paper provides estimated distributions of this population's exposures and exposure-related measurements and examines associations among the various measures via rank (Spearman) correlations. In addition, it provides some aggregate and cumulative exposure estimates for pesticides, and compares the relative intakes from inhalation and dietary ingestion. Intakes for the four primary pesticides appeared to come principally from the ingestion rather than the inhalation route; this was clearly true for chlorpyrifos but was less certain for the other three primary pesticides because of their higher degree of nondetects. Solid food rather than beverages was clearly the main contributor to the ingestion intake. Despite the dominance of the ingestion route, the urinary metabolite of chlorpyrifos exhibited a stronger association with the air measurements than with the dietary measures. Personal-air samples exhibited strong rank correlations with indoor air samples for chlorpyrifos, malathion, and diazinon (0.81, 0.51, and 0.62, respectively), while personal-air atrazine levels correlated well with outdoor levels (0.69); personal-air diazinon levels also correlated well with outdoor levels (0.67). For the PAHs, many significant associations were evident among the various air samples and for the air samples with the dust samples, especially for those compounds with consistently high percent measurable values (particularly fluoranthene, phenanthrene, and pyrene).