PROPHAGE INDUCTION AND INACTIVATION BY UV LIGHT
PROPHAGE INDUCTION AND INACTIVATION BY UV LIGHT
复制标题
DOI：
10.1128/jvi.18.3.950-955.1976
复制
发表时间：
1976-01-01
影响因子：
5.4
通讯作者：
JETT, JH
中科院分区：
文献类型：
--
作者：
BARNHART, BJ;COX, SH;JETT, JH
紫外线照射的流感嗜血杆菌溶原菌的诱导曲线和嘧啶二聚体在修复缺陷溶原菌的分布分析表明，1个二聚体每原噬菌体大小的宿主细菌染色体片段是必要的预诱导事件。获得的密切相关性提示了一个新的考虑的可能性，直接原噬菌体诱导发生时，1二聚体是稳定的原噬菌体基因组内。宿主切除-修复系统的功能显然是降低在原噬菌体内稳定那些诱导和失活所必需的二聚体的可能性。在菌株Rd中存在可诱导缺陷的前噬菌体抑制了前噬菌体HP 1c 1的诱导。
Analysis of the induction curves for UV light-irradiated Haemophilus influenzae lysogens and the distribution of pyrimidine dimers in a repair-deficient lysogen suggests that 1 dimer per prophage-size segment of the host bacterial chromosome is necessary as a preinduction event. The close correlations obtained prompted a renewed consideration of the possibility that direct prophage induction occurs when 1 dimer is stabilized within the prophage genome. The host excision-repair system apparently functions to reduce the probability of stabilizing within the prophage those dimers that are necessary for induction and inactivation. The presence of the inducible defective prophage in strain Rd depresses the inducibility of prophage HP1c1.