Incidence, prevalence, and clearance of type-specific human papillomavirus infections: The young women's health study
Incidence, prevalence, and clearance of type-specific human papillomavirus infections: The young women's health study
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DOI：
10.1086/341782
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发表时间：
2002-08-15
影响因子：
6.4
通讯作者：
Hatch, K
中科院分区：
文献类型：
--
作者：
Giuliano, AR;Harris, R;Hatch, K
在331名年龄在18-35岁的女性中检查了类型特异性人乳头瘤病毒（HPV）感染的自然史，这些女性自我转诊进行常规妇科护理。参与者在基线和基线后约4个月和约10个月接受妇科检查。在每次访问时收集宫颈样本进行HPV检测和基因分型，以及生殖，性和病史信息。新的HPV感染率为每月2.9%; HPV 16、39、84和51型的感染率最高。在基线HPV检测阴性的女性中，在12个月的随访期间获得致癌HPV菌株的累积概率为0.32，而非致癌菌株为0.18。最近有多于或等于1个新男性性伴侣的女性更有可能获得新的HPV感染（相对危险度，2.39; 95%置信区间，1.20-4.76）。致瘤菌株的感染清除中位时间（9.8个月）显著长于非致瘤菌株（4.3个月）。
The natural history of type-specific human papillomavirus (HPV) infections was examined in a cohort of 331 women aged 18-35 years who self-referred for routine gynecological care. Participants underwent a gynecological examination at baseline and at similar-to4 and similar-to10 months after baseline. Cervical samples were collected for HPV testing and genotyping at each visit, as was information on reproductive, sexual, and medical histories. The rate of new HPV infections was 2.9% per month; the highest rates were observed for HPV types 16, 39, 84, and 51. Among women who tested negative for HPV at baseline, the cumulative probability of acquiring an oncogenic HPV strain during a 12-month follow-up period was 0.32, compared with 0.18 for nononcogenic strains. Women who had had greater than or equal to1 new male sex partner in the recent past were significantly more likely to acquire a new HPV infection (relative hazard, 2.39; 95% confidence interval, 1.20-4.76). The median time to clearance of infection was significantly longer for oncogenic strains (9.8 months) than for nononcogenic strains (4.3 months).