Follow up by colour Doppler imaging of 102 patients with retinal vein occlusion over 1 year
Follow up by colour Doppler imaging of 102 patients with retinal vein occlusion over 1 year
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DOI：
10.1136/bjo.86.11.1243
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发表时间：
2002-11-01
影响因子：
4.1
通讯作者：
Tranquart, F
中科院分区：
文献类型：
--
作者：
Arsène, S;Giraudeau, B;Tranquart, F
背景/目的：视网膜静脉闭塞（RVO）是最常见的眼部血管疾病之一，可导致严重的视力损害。彩色多普勒成像（CDI）是第一种可以明确评估RVO动脉和静脉速度的方法。CDI对RVO的诊断有价值，显示了等容血稀释的效果。RVO患者通过CDI监测1年，以明确静脉和动脉参与该疾病的发病机制。方法：对RVO患者进行1年的前瞻性监测，包括临床检查、荧光素血管造影和每3个月一次的CDI。102名接受RVO治疗少于2个月的成人被纳入研究。未受影响的眼睛作为对照。测定视网膜中央动脉（CRA）的最大收缩期和舒张期血流速度和阻力指数（RI），以及视网膜中央静脉（CRV）的最大和最小血流速度。结果：观察期间，视网膜分支静脉阻塞（BRVO）、缺血性视网膜中央静脉阻塞（CRVO）和非缺血性视网膜中央静脉阻塞（CRVO）静脉流速变化规律明显。BRVO与对照组观察到的情况相似。静脉流速在中央形态持续降低，在缺血性闭塞状态下最低。相比之下，缺血性CRVO出现时动脉舒张速度短暂下降，与荧光素血管造影显示的动静脉通过时间相关，但很快恢复正常。结论：在随访期间，CDI结果与RVO类型相关。CDI表现为CRVO中心静脉流速的持续损害，而动脉流速的初始值恢复较快。这些使用CDI的结果有力地证明了RVO的原发静脉机制。
Background/aim: Retinal vein occlusion (RVO) is one of the most frequent ocular vascular diseases and leads to severe vision impairment. Colour Doppler imaging (CDI) is' the first method which allows distinct evaluation of arterial and venous velocities in RVO. CDI is valuable for diagnosis of RVO and shows the effects of isovolaemic haemodilution. Patients with RVO were monitored by CDI for 1 year in order to clarify venous and arterial involvement in the pathogenesis of this disease.Methods: Patients with RVO were monitored prospectively for 1 year with clinical examinations, fluorescein angiography, and CDI every 3 months. 102 adults referred for RVO for less than 2 months were enrolled. Unaffected eyes were used as control. The maximum systolic and diastolic flow velocities and the resistance index (RI) were measured in the central retinal artery (CRA) and the maximum and minimum blood flow velocities in the central retinal vein (CRV).Results: During the year of observation, branch retinal vein occlusion (BRVO), ischaemic central retinal vein occlusion (CRVO), and non-ischaemic CRVO had a distinct pattern of venous velocity changes. BRVO had a similar profile to that observed in controls. Venous velocities were continuously lower in central forms, with the lowest values in ischaemic occlusion. In contrast, a brief decrease in arterial diastolic velocity was observed in ischaermic CRVO at presentation, correlated with arteriovenous passage time on fluorescein angiography, but with rapid normalisation.Conclusions: CDI findings were correlated with the type of RVO at all times during, follow up. CDI showed persistent impairment of central venous velocity in CRVO whereas there was a fast initial values recovery of the arterial velocity. These results using CDI show strong evidence of a primary venous mechanism in RVO.