The time course of brain activations during response inhibition: evidence from event-related potentials in a go no go task
The time course of brain activations during response inhibition: evidence from event-related potentials in a go no go task
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DOI：
10.1097/00001756-199803090-00037
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发表时间：
1998-03-09
期刊：
影响因子：
1.7
通讯作者：
Spitzer, M
中科院分区：
文献类型：
--
作者：
Kiefer, M;Marzinzik, F;Spitzer, M
采用事件相关电位（ERP）研究了执行控制的皮层组织。当受试者执行需要反应抑制的go/no go任务时，收集ERP。首先，在刺激开始后约260 ms，在下前额区观察到反应抑制对ERPs的影响。这些地区的发电机通过源分析得到确认。后来，300 - 600毫秒之间的刺激发作后，左侧偏侧额-中央ERP的影响，发现不同的地形任务难度的非特异性影响。源性分析表明，前扣带回和左前运动区的发生器也有助于这种效果。前额叶区和前扣带回的持续激活有助于执行功能，而左侧运动前皮层的相对较晚的活动则参与运动控制。
THE cortical organization of executive control was investigated using event-related potentials (ERPs). ERPs were collected while subjects performed a go/no go task that required response inhibition. First, around 260 ms after stimulus onset, an effect of response inhibition on ERPs was observed over inferior prefrontal areas. Generators in these regions were confirmed by source analysis. Later, between 300-600 ms after stimulus onset, a left lateralized fronto-central ERP effect was found which differed in topography from a non-specific effect of task difficulty. Source analysis indicated that generators in anterior cingulate and left premotor areas also contributed to this effect. Orchestrated activation of prefrontal areas and the anterior cingulate subserves executive function whereas relatively late activity of the left premotor cortex is involved in motor control.