Systemic dissemination of glioblastoma: literature review
Systemic dissemination of glioblastoma: literature review
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DOI：
10.1590/1806-9282.65.3.460
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发表时间：
2019-03-01
期刊：
影响因子：
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通讯作者：
Marta, Gustavo Nader
中科院分区：
文献类型：
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作者：
Carvalho, Juliana Arcangelo Di Vita;Barbosa, Caroline Chaul de Lima;Marta, Gustavo Nader
简介：胶质母细胞瘤（GBM）是成人中枢神经系统最常见的原发性恶性肿瘤。然而，全身转移的存在是一个非常罕见的事件。本研究的目的是回顾文献，评估与诊断为GBM的患者发生全身转移相关的可能生物学机制。可能与GBM全身性传播相关的机制是血脑屏障破坏，通常见于GBM病例，由肿瘤本身或手术程序引起，进入血管和淋巴管，结论：肿瘤细胞必须克服许多障碍，直至全身转移的发展。其生理机制尚不完全清楚。尽管尚未完全了解，但从病理生理学上了解可能与全身性传播相关的机制对于全球了解该疾病是有益的。此外，该知识可用作在诊断为GBM远处转移的患者中进行治疗的基础。
INTRODUCTION: Glioblastoma (GBM) is the most frequent primary malignant tumor from the central nervous system in adults. However, the presence of systemic metastasis is an extremely rare event. The objective of this study was to review the literature, evaluating the possible biological mechanisms related to the occurrence of systemic metastasis in patients diagnosed with GBM.RESULTS: The mechanisms that may be related to GBM systemic dissemination are the blood-brain barrier breach, often seen in GBM cases, by the tumor itself or by surgical procedures, gaining access to blood and lymphatic vessels, associated with the acquisition of mesenchymal features of invasiveness, resistance to the immune mechanisms of defense and hostile environment through quiescence.CONCLUSIONS: Tumor cells must overcome many obstacles until the development of systemic metastasis. The physiologic mechanisms are not completely clear. Although not fully understood, the pathophysiological understanding of the mechanisms that may be associated with the systemic spread is salutary for a global understanding of the disease. In addition, this knowledge may be used as a basis for a therapy to be performed in patients diagnosed with GBM distant metastasis.