Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases.
Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases.
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DOI：
10.1111/febs.14007
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Urbé S
中科院分区：
文献类型：
--
作者：
Clague MJ;Urbé S
细胞由整合的多级蛋白质网络或系统组成。泛素、蛋白质稳态和膜运输系统高度整合。在这里，我们看看可逆的泛素化对膜运输和细胞器动力学的影响。我们回顾了内吞分选，选择性自噬和分泌途径的泛素信号的调节，特别侧重于详细介绍去泛素化酶的贡献。
The cell is comprised of integrated multilevel protein networks or systems. The ubiquitin, protein homeostasis and membrane trafficking systems are highly integrated. Here, we look at the influence of reversible ubiquitylation on membrane trafficking and organelle dynamics. We review the regulation of endocytic sorting, selective autophagy and the secretory pathway by ubiquitin signals, with a particular focus on detailing the contribution of deubiquitylating enzymes.