GEOGRAPHIC-VARIATION IN BREAST-CANCER MORTALITY IN THE UNITED-STATES - A HYPOTHESIS INVOLVING EXPOSURE TO SOLAR-RADIATION
GEOGRAPHIC-VARIATION IN BREAST-CANCER MORTALITY IN THE UNITED-STATES - A HYPOTHESIS INVOLVING EXPOSURE TO SOLAR-RADIATION
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DOI：
10.1016/0091-7435(90)90058-r
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发表时间：
1990-11-01
影响因子：
5.1
通讯作者：
YOUNG, JF
中科院分区：
文献类型：
--
作者：
GARLAND, FC;GARLAND, CF;YOUNG, JF
流行病学和实验室证据表明，维生素D可能在降低乳腺癌风险方面发挥作用。缺乏紫外线照射会增加维生素D缺乏症的患病率。这种缺陷可能会使一些人群患乳腺癌的风险更高。研究人员评估了美国87个地区每年平均照射到地面的阳光能量与年龄调整后的乳腺癌死亡率之间的关系。乳腺癌的年年龄调整死亡率在1.8倍的范围内变化，从美国南部和西南部的17-19/100，000到东北部的33/100，000;美国的整体比率为27.3/100，000。美国主要城市地区的致命性乳腺癌风险与当地阳光强度成反比（r =-0.80，P = 0.001;平流层臭氧测量的多元回归，r =-0.82，P = 0.00010）。来自阳光照射的维生素D可能与致命性乳腺癌的低风险有关，而到达美国人口的紫外线的差异可能是乳腺癌死亡率惊人的地区差异的原因。本研究的生态性质的强调，并讨论了可能性，间接与饮食和社会经济因素可以解释这些发现。
Epidemiologic and laboratory evidence suggests that vitamin D may play a role in reducing breast cancer risk. Lack of exposure to ultraviolet sunlight can increase the prevalence of vitamin D deficiency. This deficiency may place some populations at higher risk for breast cancer. The association between total average annual sunlight energy striking the ground and age-adjusted breast cancer mortality rates in 87 regions of the United States was evaluated. Annual age-adjusted mortality rates for breast cancer varied over a 1.8-fold range, from 17-19 per 100,000 in the South and Southwest United States to 33 per 100,000 in the Northeast; the overall U.S. rate was 27.3 per 100,000. Risk of fatal breast cancer in the major urban areas of the United States was inversely proportional to intensity of local sunlight (r = -0.80, P = 0.001; multiple regression with stratospheric ozone measurements, r = -0.82, P = 0.00010). Vitamin D from sunlight exposure may be associated with low risk for fatal breast cancer, and differences in ultraviolet light reaching the United States population may account for the striking regional differences in breast cancer mortality. The ecological nature of this study is emphasized, and the possibility that an indirect association with dietary and socioeconomic factors could explain these findings is discussed.