Renal allograft function in matched pediatric and adult recipient pairs of the same donor
Renal allograft function in matched pediatric and adult recipient pairs of the same donor
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DOI：
10.1097/01.tp.0000120099.92220.7a
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发表时间：
2004-04-27
期刊：
影响因子：
6.2
通讯作者：
Persijn, GG
中科院分区：
文献类型：
--
作者：
Pape, L;Offner, G;Persijn, GG
背景为了研究供体年龄对肾功能的影响，作者调查了来自同一肾脏供体的配对，供予一名儿童或一名成人患者。从欧洲移植登记处选择15对匹配的成人和儿童患者，接受来自同一尸体供体的肾移植，用于分析7年内的移植物功能。9个匹配对来自成人供体（平均年龄，40岁;范围，23-60岁），6个来自儿科供体（平均年龄，11岁;范围，4-15岁）。所有受者的免疫抑制与环孢素A，泼尼松龙，硫唑嘌呤和急性排斥反应，巨细胞病毒再激活，抗高血压治疗的数量相当。儿童和成人受者移植时的平均年龄分别为5岁（范围，1-9岁）和38岁（范围，25-60岁）。计算的肾小球滤过率（GFR）校正体表面积在成人和儿童受者中没有差异。儿童受者的初始绝对GFR（27 mL/ min;范围，17-38 mL/min）显著低于成人受者（54 mL/min;范围，25-74 mL/min）（P
Background. To study the effect of donor age on kidney function, the authors investigated matched pairs from the same kidney donor given to a pediatric or an adult recipient.Methods. Fifteen matched pairs of an adult and a pediatric patient, selected from the Eurotransplant registry, receiving the renal graft from the same cadaveric donor were selected for analysis of graft function over 7 years. Nine matched pairs were from adult donors (mean age, 40 years; range, 23-60 years) and six from pediatric donors (mean age, 11 years; range, 4-15 years). All recipients had comparable immunosuppression with cyclosporine A, prednisolone, and azathioprine and comparable numbers of acute rejection, cytomegalovirus reactivation, and antihypertensive therapy. Mean age of pediatric and adult recipients at transplantation was 5 years (range, 1-9 years) and 38 years (range, 25-60 years), respectively.Results. The calculated glomerular filtration rate (GFR) corrected to body surface area was not different in adult and pediatric recipients. Initial absolute GFR was significantly lower in pediatric recipients (27 mL/ min; range, 17-38 mL/min) than in adult recipients (54 mL/min; range, 25-74 mL/min) (P