HLA antigens in asymptomatic diabetes. A 10-year follow-up study of potential diabetes in pregnancy and gestational diabetes.
HLA antigens in asymptomatic diabetes. A 10-year follow-up study of potential diabetes in pregnancy and gestational diabetes.
复制标题
无症状糖尿病中的 HLA 抗原。
作者：
H. Mawhinney;D. Hadden;D. Middleton;J. Harley;D. Montgomery
遗传和环境因素都与糖尿病的发病机制有关。青少年发病的糖尿病已显示与HLA-B8和HLA-B15的频率增加有关（Nerup等，1974; Cudworth和Woodrow，1975），并且认为这种类型的糖尿病中的主要遗传因素是存在致糖尿病基因或与主要组织相容性复合体相关的基因。虽然双胞胎研究表明遗传因素在成熟型糖尿病中也很重要（Tattersall和Pyke，1972），但尚未证明主要组织相容性复合物抗原与成熟型糖尿病之间存在明确关联（Nerup et al，1974; Cudworth和Woodrow，1976）。
BOTH genetic and environmental factors have been implicated in the pathogenesis of diabetes mellitus. Juvenile-onset diabetes mellitus has been shown to be associated with increased frequencies of HLA-B8 and HLA-B15 (Nerup et al, 1974; Cudworth and Woodrow, 1975) and it is believed that a major genetic factor in this type of diabetes is the presence of a diabetogenic gene or genes linked to the major histocompatibility complex. While twin studies have suggested that genetic factors are also important in maturity-onset diabetes (Tattersall and Pyke, 1972) a definite association between antigens of the major histocompatibility complex and maturityonset diabetes has not been demonstrated (Nerup et al, 1974; Cudworth and Woodrow, 1976)..