Oxytocin - Behavioral associations and potential as a salivary biomarker
Oxytocin - Behavioral associations and potential as a salivary biomarker
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DOI：
10.1196/annals.1384.006
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Schwertz, Dorie
中科院分区：
文献类型：
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作者：
Carter, C. Sue;Pournajafi-Nazarloo, Hossein;Schwertz, Dorie
催产素（OT）是一种神经肽，主要在下丘脑中产生，并以其在哺乳动物出生和哺乳中的作用而闻名。最近的证据也暗示OT在社会行为中，包括父母的行为，社会纽带的形成，以及压力体验的管理。OT对压力源有反应，并在中枢和自主神经系统的调节中起作用，包括对免疫和心血管功能的影响。OT释放模式的知识将在科学和医学的许多领域具有价值。然而，血液中OT浓度的测量很少进行，并且先前测量唾液中OT的尝试一直不成功。使用敏感的酶免疫测定法（EIA）和浓缩样品，我们能够检测到可重复的变化，唾液OT作为哺乳和按摩的功能。这些结果表明，测量唾液OT的生物学相关变化是可能的。这些结果证实了唾液OT变化与应激源的生物学相关性，并支持唾液作为监测中枢神经内分泌功能的非侵入性来源。
Oxytocin (OT) is a neuropeptide that is produced primarily in the hypothalamus and is best known for its role in mammalian birth and lactation. Recent evidence also implicates OT in social behaviors, including parental behavior, the formation of social bonds, and the management of stressful experiences. OT is reactive to stressors, and plays a role in the regulation of both the central and autonomic nervous system, including effects on immune and cardiovascular function. Knowledge of patterns of OT release would be of value in many fields of science and medicine. However, measurements of OT concentration in blood are infrequently performed, and previous attempts to measure OT in saliva have been unsuccessful. Using a sensitive enzyme immunoassay (EIA) and concentrated samples we were able to detect reproducible changes in salivary OT as a function of lactation and massage. These results indicate that measurements of biologically relevant changes in salivary OT are possible. These results confirm the biological relevance of changes in salivary OT with stressors and support saliva as a noninvasive source to monitor central neuroendocrine function.