Plasma triglycerides, an independent predictor of cardiovascular disease in men:: A prospective study based on a population with prevalent metabolic syndrome
Plasma triglycerides, an independent predictor of cardiovascular disease in men:: A prospective study based on a population with prevalent metabolic syndrome
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DOI：
10.1016/j.ijcard.2005.06.056
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发表时间：
2006-03-22
影响因子：
3.5
通讯作者：
Avci, GS
中科院分区：
文献类型：
--
作者：
Onat, A;Sari, I;Avci, GS
背景和方法：我们的目的是评估空腹血浆甘油三酯是否独立预测代谢综合征高患病率人群未来的致命和非致命心血管疾病（CVD）。在土耳其成人危险因素研究中，一项以人群为基础的调查，对 2682 名 20 岁或以上的男性和女性进行了前瞻性随访，这些男性和女性在 1990 年基线检查时有空腹甘油三酯值并且没有 CVD，直到 2003/2004 年。通过酶干化学方法测量甘油三酯浓度并分层成性别特异性五分位数。有关死亡方式的信息是从一级亲属和/或当地卫生办公室的卫生人员处获得的。幸存者冠心病和中风的诊断基于病史、心血管系统体检和明尼苏达静息心电图编码。在平均 9.3 年的随访期间，成人（平均年龄 43 +/- 14）中总共发生了 120 例致命性 CVD 和 221 例新发非致命性 CVD。 结果：在对年龄、性别、BMI、收缩压、总胆固醇、降脂药物、吸烟状况和血糖调节进行调整后，逻辑回归分析中最高与最低空腹甘油三酯五分位数可显着且独立地预测 CVD。 [RR] 在男性和所有成人中分别为 2.38 和 1.79，p 均 < 0.02）。这相当于男性的风险比 (HR) 为 1.43，男女合计的风险比 (HR) 为 1.28。在同一模型中，用 HDL-胆固醇（而不是总胆固醇）进行调整也得到了显着的 HR，对应于男性为 1.42，男女合计为 1.32。结论：在代谢综合征盛行的人群中，HR 为 1.4 的男性中，空腹甘油三酯可以预测未来的 CVD，与年龄、糖尿病、降脂药物、包括总胆固醇或 HDL-C 在内的传统危险因素无关。女性适度的独立风险增量并未达到显着水平。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Background and methods: We aimed to assess whether fasting plasma triglycerides independently predicted future fatal and nonfatal cardiovascular disease (CVD) in a population having a high prevalence of the metabolic syndrome. In the Turkish Adult Risk Factor Study, a population-based survey, 2682 men and women 20 years of age or over with fasting triglyceride values available and free of CVD at baseline examination in 1990, were prospectively followed up till 2003/04. Triglyceride concentrations were measured by the enzymatic dry chemistry method and stratified into sex-specific quintiles. Information on the mode of death was obtained from first-degree relatives and/or health personnel of local health office. Diagnosis of coronary heart disease and stroke among survivors was based on history, physical examination of the cardiovascular system and Minnesota coding of resting electrocardiograms. A total of 120 fatal and 221 new nonfatal CVD occurred among adults (mean age 43 +/- 14) during a mean 9.3 years of follow-up.Results: CVD was significantly and independently predicted by the top versus the bottom fasting triglyceride quintile in logistic regression analyses when adjusted for age, sex, BMI, systolic blood pressure, total cholesterol, lipid-lowering medication, status of smoking and of glucose regulation (relative risk [RR] in men and all adults 2.38 and 1.79, respectively, p both < 0.02). This corresponded to hazard ratios (HR) of 1.43 in men and 1.28 in men and women combined. Adjustment for HDL-cholesterol instead of total cholesterol in the same model gave also significant HRs corresponding to 1.42 in men and 1.32 in sexes combined.Conclusions: Fasting triglycerides are predictive of future CVD among men with an HR of 1.4, independent of age, diabetes, lipid-lowering medication, traditional risk factors including total cholesterol or HDL-C, in a population in which metabolic syndrome prevails. A modest independent risk increment in women did not reach significance. (c) 2005 Elsevier Ireland Ltd. All rights reserved.