The route of entry of leptospires into the kidney tubule.
The route of entry of leptospires into the kidney tubule.
复制标题
钩端螺旋体进入肾小管的途径。
DOI：
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发表时间：
1976
影响因子：
3
通讯作者：
R. B. Marshall
中科院分区：
文献类型：
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作者：
R. B. Marshall
为了研究波摩那型问号钩端螺旋体通过肾脏的迁移，用该生物体腹膜内感染2或3周龄的常规饲养小鼠。在前4天内，微生物从毛细血管腔迁移到间质组织并引起间质水肿。到第10天，它们被视为近曲小管上皮细胞之间，并在第14天，许多位于管腔内。近端小管细胞内无活钩端螺旋体的证据，但偶尔观察到溶酶体内类似钩端螺旋体片段的结构。在研究期间的任何阶段均未观察到肾小球病变。
To study the migration of Leptospira interrogans serotype pomona through the kidney, conventionally-reared mice aged 2 or 3 weeks were infected intraperitoneally with this organism. Within the first 4 days, the organisms migrated from the capillary lumina to the interstitial tissue and provoked an interstitial oedema. By the 10th day they were seen between the epithelial cells of the proximal convoluted tubules and by the 14th day many were located within tubular lumina. There was no evidence of viable leptospires within the cells of the proximal tubules, though occasionally structures resembling leptospiral fragments inside lysosomes were observed. At no stage during the study were glomerular lesions seen.