Formation of Fine and Encapsulated Mefenamic Acid Particles for Dissolution Improvement via Electrospray Method
Formation of Fine and Encapsulated Mefenamic Acid Particles for Dissolution Improvement via Electrospray Method
复制标题
通过电喷雾法形成精细且封装的甲芬那酸颗粒以改善溶出度
DOI：
10.1080/02726351.2016.1246496
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发表时间：
2016
影响因子：
2.5
通讯作者：
H. Kamiya
中科院分区：
文献类型：
--
作者：
N. K. Zolkepali;N. F. Abu Bakar;M N. Naim;N. Anuar;N. F. K. Aripin;M. R. Abu Bakar;I W. Lenggoro;H. Kamiya
本研究采用静电雾化法或电喷雾法制备甲芬那酸（MA）-β-环糊精（β-CD）I型微胶囊。在水-乙醇悬浮液中制备了摩尔比为1：2的MA-βCD微胶囊，然后通过电喷雾将微滴分散成细小的干燥颗粒。电喷雾针尖和基底之间的工作距离（WD）在15至25 cm之间变化。随着WD的增加，MA-βCD颗粒的粒径从91 ± 26 nm减小到42 ± 35 nm。发现MA-βCD包封颗粒的溶出率高于收到的MA颗粒和未包封的MA颗粒。通过热分析证明了包封的MA-βCD的存在，在雾化过程之后MA峰消失。X射线衍射和红外光谱分析表明，MA与βCD之间的相互作用和C = C的出现，使包封过程中出现了新的固相。透射电子显微镜进一步分析表明，MA-βCD颗粒在水和丙酮中的尺寸和形态。包封的MA-βCD颗粒在水中溶解，但在丙酮中悬浮为球形。
The potential of using electrostatic atomizer or electrospray in producing fine and encapsulated particle of mefenamic acid (MA) form I with β-cyclodextrin (βCD) was demonstrated in this study. Encapsulated MA-βCD with a molar ratio of 1:2 was prepared in water-ethanol suspension, followed by the electrospray process to atomize the droplet into fine dried particles. The working distance (WD) between the electrospray needle tip and the substrate were varied from 15 to 25 cm. The sizes of encapsulated MA-βCD particles were found to decrease from 91 ± 26 to 42 ± 35 nm as the WD increased. The dissolution rate of encapsulated particles of MA-βCD was found to be higher compared to the particles of as-received MA and the unencapsulated MA. The presence of the encapsulated MA-βCD was proven by a thermal analysis with the disappearance of MA peak after the atomization process. The x-ray diffraction and FTIR analysis showed that the encapsulation occurred with the existence of new solid phase that was expected from interaction between MA and βCD and the appearance of C = C. Further analysis by transmission electron microscopy showed the size and morphology of MA-βCD particles when immersed in water and acetone. Encapsulated MA-βCD particles were solubilized in water but suspended as spherical shape in acetone.