Volume of ankle dorsiflexors and plantar flexors determined with stereological techniques
Volume of ankle dorsiflexors and plantar flexors determined with stereological techniques
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DOI：
10.1152/jappl.1999.86.5.1670
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发表时间：
1999-05-01
影响因子：
3.3
通讯作者：
Jakobsen, J
中科院分区：
文献类型：
--
作者：
Gadeberg, P;Andersen, H;Jakobsen, J
测定肌肉质量的方法的有效性以前没有被评估过。我们采用无假设立体技术应用于磁共振成像（MRI），通过估计肌肉体积来确定肌肉质量，研究对象为18名41岁（29-64岁，中位数，范围）的未经训练的健康受试者（6名女性，12名男性）。肌肉质量也被估计通过测量腿围和横断肌肉面积（CSA）从核磁共振成像在三个预定水平。用等速动力学法估计踝关节背屈肌和足底屈肌的功率[峰值扭矩（PT）]。背屈肌体积(r（2) = 0.76, P < 5 × 10(-6)）和CSA (r（2) = 0.73, P < 5 × 10(-5)）与PT相关，而围度与PT无关（r(2) = 0.17，无统计学意义）。相应地，足底屈肌体积（r(2) = 0.69, P < 5 × 10-5）和CSA (r（2) = 0.46, P < 5 × 10(-3)）与足底PT相关，但与腿围无关（r(2) = 0.15，无统计学意义）。背屈肌PT与体积之间的残差标准差小于足底屈肌PT与CSA之间的残差标准差（0.42 vs. 0.45） （1.5 vs. 2.0）。通过使用Cavalieri方法，6个MRI切片和15分钟的点计数足以获得下肢肌肉体积的有效估计。
The validity of the methods used for determination of muscle mass has not been evaluated previously. We determined muscle mass by estimating muscle volume with assumption-free stereological techniques applied to magnetic resonance imaging (MRI) in 18 healthy untrained subjects (6 women, 12 men) aged 41 yr (29-64 yr; median, range). Muscle mass was also estimated by measuring leg circumference and cross-sectional muscle areas (CSA) from MRIs at three predetermined levels. Power [peak torque (PT)] of the ankle dorsiflexors and plantar flexors was estimated by using isokinetic dynamometry. Dorsiflexor volume (r(2) = 0.76, P < 5 x 10(-6)) and CSA (r(2) = 0.73, P < 5 x 10(-5)) were related to PT, whereas circumference was not (r(2) = 0.17, not significant). Correspondingly, a relationship to plantar PT was established for plantar flexor volume (r(2) = 0.69, P < 5 x 10-5) and CSA (r(2) = 0.46, P < 5 x 10(-3)) but not leg circumference (r(2) = 0.15, not significant). SDs of the residuals were smaller for the relationship between dorsiflexor PT and volume than between PT and CSA (0.42 vs. 0.45) for plantar flexors (1.5 vs. 2.0). By using the Cavalieri method, six MRI sections and 15 min of point counting are sufficient to obtain a valid estimate of the volume of the muscles of the lower leg.