New natural intergenotypic (2/5) recombinant of hepatitis C virus
New natural intergenotypic (2/5) recombinant of hepatitis C virus
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DOI：
10.1128/jvi.02639-06
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发表时间：
2007-04-01
影响因子：
5.4
通讯作者：
Izopet, Jacques
中科院分区：
文献类型：
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作者：
Legrand-Abravanel, Florence;Claudinon, Julie;Izopet, Jacques
将在法国西南部发现的丙型肝炎病毒（HCV）毒株的9.2 kb序列与HCV序列数据库中参考毒株的序列进行比较。我们发现了一个基因型2在5'端和基因型5在3'端的重组病毒。交叉点位于基因NS2和NS3之间。在HCV流行病学和进化的研究中，以及在预测病毒对抗病毒治疗的反应时，必须考虑HCV基因型之间的差异。知道重组点的位置也可以用于构建感染性嵌合病毒。
A 9.2-kb sequence from a hepatitis C virus (HCV) strain found in southwest France was compared to sequences from reference strains in HCV sequence databases. We found a recombinant virus with genotype 2 at the 5' end and genotype 5 at the 3' end. The crossover point was located between genes NS2 and NS3. Recombination between HCV genotypes must now be considered in studies on HCV epidemiology and evolution and in predictions of the virus response to antiviral therapy. Knowing the location of the recombination point may also be useful for constructing infectious chimeric viruses.