Alterations in visual cortical activation and connectivity with prefrontal cortex during working memory updating in major depressive disorder.
Alterations in visual cortical activation and connectivity with prefrontal cortex during working memory updating in major depressive disorder.
复制标题
在重度抑郁症的工作记忆更新过程中，视觉皮质激活和与前额叶皮层的连通性改变了。
DOI：
10.1016/j.nicl.2017.01.004
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Leung HC
中科院分区：
文献类型：
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作者：
Le TM;Borghi JA;Kujawa AJ;Klein DN;Leung HC
本研究检测了重度抑郁症（MDD）对视觉和前额叶皮质活动以及它们在视觉工作记忆更新过程中的连接性的影响，并将其与该疾病的核心临床特征相关联。工作记忆更新受损通常与无关负面信息的保留有关，这可能导致持续的抑郁情绪和异常情感。然而，在涉及很少或不涉及情绪处理需求的任务中，已在MDD中观察到表现缺陷，这表明功能障碍也可能发生在更基础的信息处理层面。然而，尚不清楚视觉工作记忆回路中的各个区域如何导致MDD中的行为变化。我们获取了18名未服药的MDD参与者和21名年龄匹配的健康对照（CTL）在执行以中性面孔和场景作为任务刺激的视觉延迟识别任务时的功能性磁共振成像数据。通过在延迟期插入一个提示来操纵选择性工作记忆更新，以表明两个记忆中的刺激（一个面孔和一个场景）中的哪一个或两个对于识别测试仍然相关。我们的结果揭示了几个关键发现。与CTL组相比，MDD组在面孔和场景工作记忆的选择性维持过程中，视觉联合区的提示后激活较弱。在MDD受试者中，更严重的反刍和抑郁症状与更多与不再相关的任务信息有关的持续激活和连接性相关。与健康对照相比，MDD受试者中场景相关区域的提示后空间激活模式的分类也不太一致。这种异常似乎是由于MDD组中前额叶和场景相关区域之间提示后功能连接缺乏更新效应所致。总之，MDD中工作记忆更新的中断通过视觉联合区活动模式的改变、它们与前额叶皮质的连接以及它们与核心临床特征的关系得以揭示。这些结果凸显了信息更新缺陷在抑郁症的认知控制和症状学中的作用。
未服药的重度抑郁症患者在视觉工作记忆更新过程中表现出几种形式的缺陷。
视觉工作记忆更新表现受损。
视觉联合区特定类别反应模式减弱，特别是那些涉及场景处理的区域。
在场景信息更新过程中，与场景选择性视觉区域的额叶功能连接丧失。
反刍与工作记忆中过时信息的活动增强和功能连接相关。
The present study examined the impacts of major depressive disorder (MDD) on visual and prefrontal cortical activity as well as their connectivity during visual working memory updating and related them to the core clinical features of the disorder. Impairment in working memory updating is typically associated with the retention of irrelevant negative information which can lead to persistent depressive mood and abnormal affect. However, performance deficits have been observed in MDD on tasks involving little or no demand on emotion processing, suggesting dysfunctions may also occur at the more basic level of information processing. Yet, it is unclear how various regions in the visual working memory circuit contribute to behavioral changes in MDD. We acquired functional magnetic resonance imaging data from 18 unmedicated participants with MDD and 21 age-matched healthy controls (CTL) while they performed a visual delayed recognition task with neutral faces and scenes as task stimuli. Selective working memory updating was manipulated by inserting a cue in the delay period to indicate which one or both of the two memorized stimuli (a face and a scene) would remain relevant for the recognition test. Our results revealed several key findings. Relative to the CTL group, the MDD group showed weaker postcue activations in visual association areas during selective maintenance of face and scene working memory. Across the MDD subjects, greater rumination and depressive symptoms were associated with more persistent activation and connectivity related to no-longer-relevant task information. Classification of postcue spatial activation patterns of the scene-related areas was also less consistent in the MDD subjects compared to the healthy controls. Such abnormalities appeared to result from a lack of updating effects in postcue functional connectivity between prefrontal and scene-related areas in the MDD group. In sum, disrupted working memory updating in MDD was revealed by alterations in activity patterns of the visual association areas, their connectivity with the prefrontal cortex, and their relationship with core clinical characteristics. These results highlight the role of information updating deficits in the cognitive control and symptomatology of depression. Unmedicated individuals with major depressive disorder showed several forms of deficits during visual working memory updating. Impaired visual working memory updating performance. Diminished category-specific response patterns in visual association areas, particularly those involved in scene processing. Loss of frontal functional connectivity with the scene-selective visual region during updating of scene information. Rumination is associated with heightened activity and functional connectivity for obsolete information in working memory.