Substance P immunoreactivity in Rett syndrome
Substance P immunoreactivity in Rett syndrome
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DOI：
10.1016/s0887-8994(00)00120-x
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发表时间：
2000-04-01
影响因子：
3.8
通讯作者：
Armstrong, DD
中科院分区：
文献类型：
--
作者：
Deguchi, K;Antalffy, BA;Armstrong, DD
Rett 综合征 (RS) 发生严重的自主神经功能障碍，RS 患者脑脊液中的 P 物质（一种定位于包括自主神经系统在内的多个大脑区域的速激肽）减少。14 例 Rett 综合征患者脑中 P 物质免疫反应性和胶质纤维酸性蛋白阳性星形胶质细胞的解剖定位和强度 RS 与 10 名年龄匹配的正常患者大脑中的 RS 进行了比较。与对照组织相比，RS 组织中以下区域的 P 物质免疫反应性表达显着降低：背角、脊髓中间外侧柱、三叉神经束、孤立束和核、小细胞核和脑桥网状核、蓝斑，黑质、中央灰质中 P 物质免疫反应性降低不显着。 中脑、额叶皮层、尾状核、壳核、苍白球和丘脑，P物质免疫反应性降低的区域和其他脑区域的抗神经胶质原纤维酸性蛋白阳性星形胶质细胞增加。由于许多 P 物质免疫反应性下降幅度最大的脑区参与自主神经系统的控制，特别是孤束和网状结构，因此 P 物质减少可能会导致 RS 中的自主神经功能障碍。 (C) 2000 年，Elsevier Science Inc. 保留所有权利。
Severe autonomic dysfunction occurs in Rett syndrome (RS), Substance P, a tachykinin peptide that localizes to several brain regions, including the autonomic nervous system, is reduced in the cerebrospinal fluid of patients with RS, The anatomic localization and intensity of substance P immunoreactivity and glial fibrillary acidic protein-positive astrocytes in the brains of 14 patients with RS were compared with those in the brains of 10 age-matched normal patients. Substance P immunoreactivity expression was significantly decreased in RS tissue compared with control tissue in the following regions: dorsal horns, intermediolateral column of the spinal cord, spinal trigeminal tract, solitary tract and nucleus, parvocellular and pontine reticular nuclei, and locus ceruleus, A less significant decrease of substance P immunoreactivity occurred in the substantia nigra, central gray of the midbrain, frontal cortex, caudate, putamen, globus pallidus, and thalamus, Antiglial fibrillary acidic protein-positive astrocytes were increased in the areas in which substance P immunoreactivity was decreased and in other brain regions. Because many of the brain regions with the greatest decrease in substance P immunoreactivity are involved in the control of the autonomic nervous system, especially the solitary tracts and reticular formation, reduced substance P may contribute to the autonomic dysfunction in RS. (C) 2000 by Elsevier Science Inc. All rights reserved.