Stemming the Degeneration: IVD Stem Cells and Stem Cell Regenerative Therapy for Degenerative Disc Disease.
Stemming the Degeneration: IVD Stem Cells and Stem Cell Regenerative Therapy for Degenerative Disc Disease.
复制标题
DOI：
10.5171/2013.724547
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Sivakamasundari V;T. Lufkin
中科院分区：
文献类型：
--
作者：
Sivakamasundari V;T. Lufkin
椎间盘（IVD）对脊柱功能的完整性非常重要。高度专业化的IVD功能赋予脊柱柔韧性和抗拉强度，并承受各种类型的生物力学力。退行性椎间盘疾病（DDD）是一种常见的肌肉骨骼疾病，是腰痛的主要原因，包括更严重的退行性腰椎侧凸、椎间盘突出和椎管狭窄。DDD是一种多因素疾病，合成代谢和分解代谢因子的失衡、细胞组成的改变、生物物理刺激和遗传背景都可能在其发病中发挥作用。然而，我们对IVD的形成和椎间盘退变（DD）的病因学的理解还远远不够完整，这阻碍了制定适当的治疗方法来治疗DD的努力。干细胞的知识和各种技术来操纵和指导它们的特定命运，在采用基于干细胞的再生方法治疗DD方面很有希望。干细胞/祖细胞在特定IVD壁龛内驻留的新证据已经出现，为未来的治疗应用带来了希望。与当前治疗方法有关的现有问题也包括在本综述中。
The intervertebral disc (IVD) is immensely important for the integrity of vertebral column function. The highly specialized IVD functions to confer flexibility and tensile strength to the spine and endures various types of biomechanical force. Degenerative disc disease (DDD) is a prevalent musculoskeletal disorder and is the major cause of low back pain and includes the more severe degenerative lumbar scoliosis, disc herniation and spinal stenosis. DDD is a multifactorial disorder whereby an imbalance of anabolic and catabolic factors, or alterations to cellular composition, or biophysical stimuli and genetic background can all play a role in its genesis. However, our comprehension of IVD formation and theetiology of disc degeneration (DD) are far from being complete, hampering efforts to formulate appropriate therapies to tackle DD. Knowledge of the stem cells and various techniques to manipulate and direct them to particular fates have been promising in adopting a stem-cell based regenerative approach to DD. Moreover, new evidence on the residence of stem/progenitor cells within particular IVD niches has emerged holding promise for future therapeutic applications. Existing issues pertaining to current therapeutic approaches are also covered in this review.