Volumetric bone mineral density at the spine and hip in Chinese American and White women.
Volumetric bone mineral density at the spine and hip in Chinese American and White women.
复制标题
美国华裔和白人女性脊柱和臀部的体积骨矿物质密度。
DOI：
10.1007/s00198-011-1855-z
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Bilezikian,JP
中科院分区：
文献类型：
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作者：
Walker,MD;Saeed,I;McMahon,DJ;Udesky,J;Liu,G;Lang,T;Bilezikian,JP
本研究评估了绝经前后的美籍华人和白色女性脊柱和髋部骨大小和体积密度的种族差异。与白色妇女相比，华裔美国妇女有更大的皮质体积骨密度（vBMD）在髋关节，与结果一致，在外周skeleton.IntroductionChinese美国妇女有较低的骨折率比白色妇女，尽管较低的面积骨密度。然而，在前臂和胫骨，与白色女性相比，华裔美国女性具有更高的皮质vBMD以及更大的小梁和皮质厚度，但通过高分辨率外周定量计算机断层扫描（HR-pQCT）测量的骨面积更小。由于HR-pQCT数据是在外周部位获得的，因此尚不清楚这些差异是否与具有临床意义的腰椎和髋关节相关。本研究评估了种族差异的骨大小和vBMD在脊柱和髋关节在美国华人和白色women.MethodsQCT的脊柱和髋关节进行了测量，以评估种族差异的骨大小，结构，和vBMD在绝经前（n= 83）和绝经后（n= 50）的美国华人和白色妇女。数据进行了调整，体重，身高，体力活动，总钙摄入量，甲状旁腺激素，和25-羟基维生素D levels.ResultsAmong绝经前women，腰椎骨小梁vBMD是5.8%以上的中国美国人与白色妇女（p= 0.01）。在髋部，与白色女性相比，绝经前美籍华人女性股骨颈皮质vBMD高3%（p= 0.05），全髋高3.6%（p= 0.01）。在绝经后妇女中，腰椎骨小梁vBMD无差异。皮质vBMD是4%以上，在全髋关节（p= 0.02），往往是更大的股骨颈（p= 0.058）在美国华人与白色women. ConclusionsConsistently与早期发现在外周骨骼，皮质vBMD是更大的髋关节在美国华人与白色妇女。
SummaryThis study evaluated racial differences in bone size and volumetric density at the spine and hip in pre- and postmenopausal Chinese American and White women. Compared with White women, Chinese American women have greater cortical volumetric bone density (vBMD) at the hip, congruent with the results at the peripheral skeleton.IntroductionChinese American women have lower rates of fracture than White women despite lower areal bone density. At the forearm and tibia, however, Chinese American women have higher cortical vBMD as well as greater trabecular and cortical thickness, but smaller bone area as measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) compared with White women. Since HR-pQCT data are obtained at peripheral sites, it is unclear whether these differences are relevant to the clinically important lumbar spine and hip. This study assesses racial differences in bone size and vBMD at the spine and hip in Chinese American and White women.MethodsQCT of the spine and hip was measured to assess racial differences in bone size, structure, and vBMD in pre- (n= 83) and postmenopausal (n= 50) Chinese American and White women. Data were adjusted for weight, height, physical activity, total calcium intake, parathyroid hormone, and 25-hydroxyvitamin D levels.ResultsAmong premenopausal women, lumbar spine trabecular vBMD was 5.8% greater in Chinese American versus White women (p= 0.01). At the hip, cortical vBMD was 3% greater at the femoral neck (p= 0.05) and 3.6% greater at the total hip (p= 0.01) in premenopausal Chinese American compared with White women. Among postmenopausal women, there was no difference in lumbar spine trabecular vBMD. Cortical vBMD was 4% greater at the total hip (p= 0.02) and tended to be greater at the femoral neck (p= 0.058) in Chinese American versus White women.ConclusionsConsistent with earlier findings in the peripheral skeleton, cortical vBMD is greater at the hip in Chinese American versus White women.