Detection of autoantibodies against GABAARα1 in patients with schizophrenia.
Detection of autoantibodies against GABAARα1 in patients with schizophrenia.
复制标题
精神分裂症患者GABAARα1自身抗体的检测。
DOI：
10.1016/j.schres.2019.10.007
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Takahashi H.
中科院分区：
文献类型：
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作者：
Shiwaku H;Nakano Y;Kato M;Takahashi H.
最近的研究已经在脑炎患者中发现了针对突触分子的自身抗体。针对N-甲基-d-天冬氨酸受体的自身抗体已在精神分裂症患者中报道;然而，针对其他分子的自身抗体尚未确定。这项研究使用了一种基于细胞的检测方法来检测精神分裂症患者和健康对照者的血清样本。结果表明，57例精神分裂症患者中有5例（8.6%）携带抗γ-氨基丁酸A受体α1亚单位（GABAARα1）的自身抗体，目前尚不清楚这种抗体与精神分裂症的病理学有关。一些患者显示出明显高的抗体滴度（即，1：10，000 - 100，000）。健康对照受试者中无GABAARα1抗体阳性。因此，这些自身抗体可能形成GABA介导的病理学在精神分裂症患者的一个亚组的基础。
Recent studies have identified autoantibodies against synaptic molecules in patients with encephalitis. Autoantibodies against theN-Methyl-d-Aspartate receptor have been reported in patients with schizophrenia; however, autoantibodies against other molecules are yet to be identified. This study used a cell-based assay to examine serum samples from individuals with schizophrenia and healthy controls. The results showed that 5 (8.6%) of 57 patients with schizophrenia harbor autoantibodies against the α1 subunit of the γ-aminobutyric acid A receptor (GABAARα1), which are currently not know to be linked to the pathology of this disease. Some patients showed markedly high antibody titers (i.e., 1:10,000–100,000). None of the heathy control subjects were positive for GABAARα1 antibodies. Therefore, these autoantibodies may form the basis of GABA-mediated pathology in a subgroup of patients with schizophrenia.