GLUCOSE-TOLERANCE AND INSULIN-SECRETION IN EXPERIMENTAL PANCREATIC-CANCER IN THE SYRIAN-HAMSTER
GLUCOSE-TOLERANCE AND INSULIN-SECRETION IN EXPERIMENTAL PANCREATIC-CANCER IN THE SYRIAN-HAMSTER
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DOI：
10.1007/bf02576207
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发表时间：
1993-02-01
期刊：
影响因子：
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通讯作者：
ANDRENSANDBERG, A
中科院分区：
文献类型：
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作者：
AHREN, B;ANDRENSANDBERG, A
在叙利亚金黄仓鼠中，每周皮下给予N-亚硝基双（2-氧丙基）胺6周后，约25周时发生胰腺癌。本实验研究了胰腺癌发生发展过程中糖耐量和胰岛素分泌的变化。治疗开始后每6周，静脉输注葡萄糖30分钟（10 mg/min）。结果发现，与年龄匹配的盐水注射对照组相比，葡萄糖耐量和葡萄糖刺激的胰岛素分泌在治疗开始后6周、12周和18周均正常。相比之下，在24、30和42周后，在葡萄糖输注期间发生了夸大的血浆葡萄糖反应和伴随的血浆胰岛素反应受损（P < 0.05）。因此，我们得出结论，胰腺癌的发展，在这个模型是伴随着葡萄糖耐受不良和胰岛素分泌受损，这些影响发生伴随着癌症的发展。
Pancreatic cancer develops at approximately 25 weeks after 6 weeks of weekly subcutaneous administration of N-nitrosobis (2-oxypropyl)amine in the Syrian golden hamster. We studied the glucose tolerance and insulin secretion during the development of pancreatic cancer in this model. Every 6th week after start of treatment, glucose was infused intravenously for 30 min (10 mg/min). It was found that the glucose tolerance and glucose-stimulated insulin secretion were normal at 6, 12, and 18 weeks after start of treatment compared with age-matched saline-injected controls. By contrast, after 24, 30, and 42 weeks an exaggerated plasma-glucose response and a concomitant impaired plasma-insulin response occurred during the glucose infusion (P < 0.05). We therefore conclude that the development of pancreatic cancer in this model is accompanied by glucose intolerance and impaired insulin secretion, and that these effects occur concomitantly with the development of cancer.