Cervical determinants of anal HPV infection and high-grade anal lesions in women: a collaborative pooled analysis
Cervical determinants of anal HPV infection and high-grade anal lesions in women: a collaborative pooled analysis
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DOI：
10.1016/s1473-3099(19)30164-1
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发表时间：
2019-08-01
影响因子：
56.3
通讯作者：
Clifford, Gary M.
中科院分区：
文献类型：
--
作者：
Lin, Chunqing;Slama, Jiri;Clifford, Gary M.
背景宫颈癌筛查可能有助于预防女性肛门癌。我们的目的是调查，如果常规宫颈癌筛查结果，即高危型人乳头瘤病毒（HPV）感染和细胞组织病理学预测肛门HPV 16感染，肛门高级鳞状上皮内病变（HSIL），因此，anal cancer.Methods我们做了一个系统的审查MEDLINE，Embase和科克伦图书馆的研究肛门HPV和HSIL的宫颈决定因素发表到2018年8月31日。我们集中重新分析了来自36项研究的13427名妇女的配对宫颈和肛门样本的个人水平数据。我们使用患病率（PR）和95%CI，按艾滋病毒状态、宫颈高危HPV、宫颈细胞组织病理学、年龄及其组合比较了肛门高危HPV的患病率。在3255名女性肛门细胞病理学结果，PR同样计算所有肛门HSIL和HPV 16阳性肛门HSIL.Findings宫颈和肛门HPV感染高度相关。在HIV阴性的妇女中，宫颈HPV 16阳性的肛门HPV 16感染率为41%（447/1097），宫颈HPV 16阴性的肛门HPV 16感染率为2%（214/8663）（PR 16.5，95%CI 14.2-19.2，p
Background Cervical cancer screening might contribute to the prevention of anal cancer in women. We aimed to investigate if routine cervical cancer screening results-namely high-risk human papillomavirus (HPV) infection and cytohistopathology-predict anal HPV16 infection, anal high-grade squamous intraepithelial lesions (HSIL) and, hence, anal cancer.Methods We did a systematic review of MEDLINE, Embase, and the Cochrane library for studies of cervical determinants of anal HPV and HSIL published up to Aug 31, 2018. We centrally reanalysed individual-level data from 13 427 women with paired cervical and anal samples from 36 studies. We compared anal high-risk HPV prevalence by HIV status, cervical high-risk HPV, cervical cytohistopathology, age, and their combinations, using prevalence ratios (PR) and 95% CIs. Among 3255 women with anal cytohistopathology results, PRs were similarly calculated for all anal HSIL and HPV16-positive anal HSIL.Findings Cervical and anal HPV infections were highly correlated. In HIV-negative women, anal HPV16 prevalence was 41% (447/1097) in cervical HPV16-positive versus 2% (214/8663) in cervical HPV16-negative women (PR 16.5, 95% CI 14.2-19.2, p