Using digital image correlation to determine bone surface strains during loading and after adaptation of the mouse tibia
Using digital image correlation to determine bone surface strains during loading and after adaptation of the mouse tibia
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DOI：
10.1016/j.jbiomech.2009.10.042
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发表时间：
2010-03-03
影响因子：
2.4
通讯作者：
Shefelbine, Sandra
中科院分区：
文献类型：
--
作者：
Sztefek, Pavel;Vanleene, Maximilien;Shefelbine, Sandra
先前的皮质骨适应模型，其中载荷施加在骨上，已经使用应变计、分析梁理论或有限元分析来估计组织中的应变。我们使用数字图像相关（DIC），跟踪在加载过程中的骨表面上的散斑图案，以确定在通过膝关节的压缩载荷过程中的小鼠胫骨的表面应变。我们研究了这些表面应变在小鼠胫骨是否修改后两个星期的负荷诱导的适应与对侧对照比较。结果表明，不均匀的应变模式与孤立的高应变区（0.5%），特别是在内侧。应变测量是可重复的（误差的标准偏差0.03%），样本之间相似，并与应变计测量（0.1和0.2%之间的应变）。结构调整后，胫骨表面的应变更加均匀，特别是内侧，峰值应变从0.5%降低到0.3%。由于DIC确定了整个表面上的局部应变，因此它将更好地理解应变刺激如何影响适应期间的骨反应。皇冠版权所有（C）2009由爱思唯尔有限公司出版。保留所有权利。
Previous models of cortical bone adaptation, in which loading is imposed on the bone, have estimated the strains in the tissue using strain gauges, analytical beam theory, or finite element analysis. We used digital image correlation (DIC), tracing a speckle pattern on the surface of the bone during loading, to determine surface strains in a murine tibia during compressive loading through the knee joint. We examined whether these surface strains in the mouse tibia are modified following two weeks of load-induced adaptation by comparison with contralateral controls. Results indicated non-uniform strain patterns with isolated areas of high strain (0.5%), particularly on the medial side. Strain measurements were reproducible (standard deviation of the error 0.03%), similar between specimens, and in agreement with strain gauge measurements (between 0.1 and 0.2% strain). After structural adaptation, strains were more uniform across the tibial surface, particularly on the medial side where peak strains were reduced from 0.5% to 0.3%. Because DIC determines local strains over the entire surface, it will provide a better understanding of how strain stimulus influences the bone response during adaptation. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.