Brain maturation and subtypes of conduct disorder: Interactive effects on P300 amplitude and topography in male adolescents
Brain maturation and subtypes of conduct disorder: Interactive effects on P300 amplitude and topography in male adolescents
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DOI：
10.1097/00004583-200301000-00017
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发表时间：
2003-01-01
影响因子：
13.3
通讯作者：
Hesselbrock, VM
中科院分区：
文献类型：
--
作者：
Bauer, LO;Hesselbrock, VM
Objective.平均而言，有品行障碍问题的青少年在各种不幸的成年后果方面的风险增加，包括物质依赖。本研究旨在确定不同类别的行为障碍问题的神经生理学相关性，以及这些相关性和大脑的成熟状态之间的关系。方法：研究对象为94名男性，年龄14-19岁。没有人是从治疗或少年司法项目中招募的。受试者在15岁之前表现出的行为问题行为的类型和数量各不相同。根据DSM-IV行为障碍诊断标准的相对数量（0与大于或等于1），在以下四个类别中的每一个类别中定义组：规则性、攻击性、欺骗性/盗窃性和破坏性。年龄作为额外的分组因素纳入。PWO脑电电位被记录，而受试者，执行一项任务，其中罕见的听觉刺激被用来在随后的一组试验中的刺激反应映射的变化信号。结果;分析表明，男孩的历史规则的违规行为未能表现出正常的成熟的P300振幅的增加，发现在男孩没有历史的规则违规行为。电流源密度的地形分析表明，成熟赤字的来源涉及P300发电机在额叶脑。P300的顶叶发生器正常成熟。结论：目前的结果被解释为反映了在物质依赖，反社会人格障碍，或其他形式的成人精神病理学的潜在风险的男孩额叶脑成熟的递减
Objective. Adolescents with conduct disorder problems are, on average, at increased risk for a variety of unfortunate adult outcomes, including substance dependence. This study was designed to identify the neurophysiological correlates of different categories of conduct disorder problems as well as the relationship between these correlates and the maturational status of the brain. Method: The subjects were 94 males, aged 14-19 years, recruited from the community. None were recruited from treatment or juvenile justice programs. The subjects varied in the type and number of conduct problem behaviors exhibited prior to age 15. Groups were operationally defined by the relative number (0 versus greater than or equal to1) of DSM-IV conduct disorder diagnostic criteria within each of four categories: rules Volations, aggression, deceitfufness/theft and destructiveness. Age was included as an additional grouping factor. PWO electroencephalographic potentials were recorded while subjects, performed a task in which rare auditory stimuli were used to signal a change in stimulus-response mapping during a succeeding set of trials. Results; Analyses revealed that boys with a history of rules violations failed to exhibit the normal maturational increase in P300 amplitude found in boys without a history of rules Violations. Topographic analyses of current source densities suggest that the source of the maturational deficit involved P300 generators within the frontal brain. Parietal generators of P300 matured normally. Conclusions: The present results are interpreted as reflecting a decrement in frontal brain maturation among boys potentially at risk for substance dependence, antisocial personality disorder, or other forms of adult psychopathology