EFFECT OF THE ANTI-ESTROGEN CI-628 ON ANDROGEN-INDUCED AGGRESSIVE-BEHAVIOR IN CASTRATED MALE-MICE
EFFECT OF THE ANTI-ESTROGEN CI-628 ON ANDROGEN-INDUCED AGGRESSIVE-BEHAVIOR IN CASTRATED MALE-MICE
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DOI：
10.1016/0018-506x(79)90002-3
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发表时间：
1979-01-01
影响因子：
3.5
通讯作者：
NOWELL, NW
中科院分区：
文献类型：
--
作者：
CLARK, CR;NOWELL, NW
研究了抗雌激素CI-628是否会阻断去势雄性小鼠中睾酮维持的战斗。将TO品系成年雄性小鼠阉割并皮下注射。每天用75 μ g睾酮或75 μ g睾酮和1 mg CI-628，另外在每次注射抗雌激素和雄激素前6小时用1 mg CI-628，持续14天。将溶剂注射、去势和CI-628注射的动物用作对照。雄激素维持的雄性间攻击行为被抗雌激素CI-628阻断。睾酮通过芳构化为雌激素代谢物对参与攻击行为控制的中枢神经元件发挥作用的假设得到了支持。
Whether or not the antiestrogen CI-628 would block testosterone-maintained fighting in castrated male mice was studied. TO strain adult male mice were castrated and injected s.c. every day for 14 days with either 75 .mu.g testosterone or 75 .mu.g testosterone and 1 mg CI-628, and, in addition, 1 mg of CI-628 6 h prior to each injection of antiestrogen and androgen. Vehicle-injected, castrated and CI-628-injected animals were employed as controls. Testosterone-maintained intermale aggressive behavior was blocked by the antiestrogen CI-628. The hypothesis that testosterone exerts its effects on the central nervous elements involved in the control of aggressive behavior by its aromatization to estrogenic metabolites was supported.