Modification of Nanoparticles with Transferrin for Targeting Brain Tissues.
Modification of Nanoparticles with Transferrin for Targeting Brain Tissues.
复制标题
用转铁蛋白修饰纳米颗粒以靶向脑组织。
DOI：
10.1007/978-1-0716-1617-8_5
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Torchilin,VladimirP
中科院分区：
文献类型：
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作者：
Attia,SaraAly;Li,Xiang;Filipczak,Nina;Costa,DanielF;Torchilin,VladimirP
将治疗药物输送到脑组织是神经病理学的主要挑战之一。在过去的二十年里，各种各样的药物输送系统被设计成针对血脑屏障的成分，包括转铁蛋白受体，一种在脑内皮中高度表达的跨膜糖蛋白。在这个方案中，我们描述了使用转铁蛋白来激活纳米颗粒的表面，目的是指导它们在大脑中的吸收。该分子由酰胺连接器结合到聚乙二醇化的脂质上，通常用于制备脂质纳米颗粒、胶束和脂质体。
The delivery of therapeutics to brain tissues is one of the main challenges in neuropathology. For the past two decades, a variety of drug delivery systems has been designed to target components of the blood-brain barrier, including the transferrin receptor, a transmembrane glycoprotein highly expressed in the brain endothelium.In this protocol, we describe the use of transferrin protein to activate the surface of nanoparticles with the aim to direct their uptake in the brain. The molecule is bound by an amide linker to a PEGylated lipid commonly used in the preparation of lipid nanoparticles, micelles, and liposomes.