Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a useful marker for early-stage carotid atherosclerosis
Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a useful marker for early-stage carotid atherosclerosis
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DOI：
10.1016/j.metabol.2009.09.009
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发表时间：
2010-05-01
影响因子：
9.8
通讯作者：
Nakamura, Motoyuki
中科院分区：
文献类型：
--
作者：
Tamada, Makiko;Makita, Shinji;Nakamura, Motoyuki
低密度脂蛋白胆固醇（LDL-C）与高密度脂蛋白胆固醇（HDL-C）的比率越高，冠心病患者发生心血管事件的风险就越大。然而，该脂质指数在早期动脉粥样硬化期间的作用尚未确定。本研究调查了 LDL-C/HDL-C 比值与颈动脉斑块评分之间的关系，通过超声检查对来自普通人群的 825 名受试者（527 名男性，298 名女性；平均年龄，60.5 岁）进行评估。为了确定与斑块评分密切相关的因素，使用包括常规脂质指数在内的各种临床变量进行逐步多元回归分析。在男女中，LDL-C/HDL-C 比率增加与斑块评分增加相关（男性：β = 0.132，P = .001；女性：β = 0.150，P = .012）。这种关联在 LDL-C 水平正常的男性中得以维持（男性为 2.9，女性为 >2.6），即使在逐步分析最终模型中包含的因素进行调整后，斑块评分也显着增加（男性 P = .007，女性 P = .033）。在多变量调整模型中，未发现 LDL-C 与斑块评分之间存在关联。这些发现表明，LDL-C/HDL-C 比率升高也可能与动脉粥样硬化的发生有关。因此，与单独评估 LDL-C 相比，评估这种脂质比率可能更好地促进动脉粥样硬化风险的早期管理。 (C) 2010 Elsevier Inc. 保留所有权利。
A higher ratio of low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C) is associated with a greater risk of cardiovascular events in patients with coronary heart disease. However, the role of this lipid index during early-stage atherosclerosis has not yet been established. This study investigated relationships between LDL-C/HDL-C ratio and carotid plaque score as assessed by ultrasonography in 825 subjects from the general population (527 men, 298 women; mean age, 60.5 years). To identify factors strongly associated with plaque score, stepwise multiple regression analysis was performed using various clinical variables including conventional lipid indices. In both sexes, increased LDL-C/HDL-C ratio was associated with increased plaque score (men: beta = 0.132, P = .001; women: beta = 0.150,P = .012). This association was maintained in men with normal LDL-C level (2.9 in men, >2.6 in women) showed significantly increased plaque score even when adjusted by factors included in the final model of stepwise analysis (P = .007 in men, P = .033 in women). No association was seen between LDL-C and plaque score in the multivariate-adjusted model. These findings indicate that increased LDL-C/HDL-C ratio may also be associated with initiation of atherosclerosis. Assessment of this lipid ratio may thus facilitate early management of atherosclerotic risks better rather than assessment of LDL-C alone. (C) 2010 Elsevier Inc. All rights reserved.