Potential of Cell Surface Engineering with Biocompatible Polymers for Biomedical Applications
Potential of Cell Surface Engineering with Biocompatible Polymers for Biomedical Applications
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生物相容性聚合物细胞表面工程在生物医学应用中的潜力
DOI：
10.1021/acs.langmuir.0c01678
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发表时间：
2020
期刊：
影响因子：
3.9
通讯作者：
Ishihara Kazuhiko
中科院分区：
文献类型：
--
作者：
Teramura Yuji;Ekdahl Kristina Nilsson;Fromell Karin;Nilsson Bo;Ishihara Kazuhiko
生物材料对细胞表面的调控有助于生物医学应用的进步。特别是，细胞表面在移植治疗中暴露在免疫学监测和反应中，细胞表面属性的调节可能会改善移植结果。治疗性细胞、组织和器官移植是一种有效的基础治疗方法，有助于挽救生命和提高生活质量。由于短缺，捐赠者的细胞、组织和器官被谨慎地移植，目的是保持活力和生存能力。然而，在减少副作用、提高移植物存活率、管理先天和获得性免疫反应以及改进移植储存和程序方面，仍有一些问题有待解决。鉴于移植过程涉及多个步骤，而且技术复杂，工程方法与解决这些问题的医学方法相结合可能会提高成功。特别是，具有生物相容性聚合物的细胞表面工程在改善移植治疗方面看起来很有希望，并具有其他生物医学应用的潜力。在这里，我们综述了基于聚合物的细胞和器官表面修饰在生物医学应用中的重要性，重点讨论了以下三个主题：细胞保护：通过生物相容聚合物修饰细胞表面的局部免疫调节来保护细胞。这种保护可以扩展到防止宿主免疫系统的攻击，使受者免于服用免疫抑制药物，并避免二次移植。细胞附着：细胞操作，这是在再生治疗中运送治疗细胞及其排列的重要技术，用于使脱细胞的组织和器官重新细胞化。细胞融合：不同细胞的融合，可以导致新的功能细胞的形成，这些细胞可能有助于产生免疫活性或代谢活性细胞。
The regulation of the cellular surface with biomaterials can contribute to the progress of biomedical applications. In particular, the cell surface is exposed to immunological surveillance and reactions in transplantation therapy, and modulation of cell surface properties might improve transplantation outcomes. The transplantation of therapeutic cells, tissue, and organs is an effective and fundamental treatment and has contributed to saving lives and improving quality of life. Because of shortages, donor cells, tissues, and organs are carefully transplanted with the goal of retaining activity and viability. However, some issues remain to be resolved in terms of reducing side effects, improving graft survival, managing innate and adaptive immune responses, and improving transplant storage and procedures. Given that the transplantation process involves multiple steps and is technically complicated, an engineering approach together with medical approaches to resolving these issues could enhance success. In particular, cell surface engineering with biocompatible polymers looks promising for improving transplantation therapy and has potential for other biomedical applications. Here we review the significance of polymer-based surface modification of cells and organs for biomedical applications, focusing on the following three topics:Cell protection: cellular protection through local immune regulation using cell surface modification with biocompatible polymers. This protection could extend to preventing attack by the host immune system, freeing recipients from taking immunosuppressive drugs, and avoiding a second transplantation.Cell attachment: cell manipulation, which is an important technique for delivery of therapeutic cells and their alignment for recellularization of decellularized tissues and organs in regenerative therapy.Cell fusion: fusion of different cells, which can lead to the formation of new functional cells that could be useful for generating, e.g., immunologically competent or metabolically active cells.