Viral RNA silencing suppressors (RSS): novel strategy of viruses to ablate the host RNA interference (RNAi) defense system.
Viral RNA silencing suppressors (RSS): novel strategy of viruses to ablate the host RNA interference (RNAi) defense system.
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DOI：
10.1016/j.virusres.2010.10.003
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发表时间：
2011-01
期刊：
影响因子：
5
通讯作者：
Chauhan, Ashok
中科院分区：
文献类型：
--
作者：
Bivalkar-Mehla, Shalmali;Vakharia, Janaki;Mehla, Rajeev;Abreha, Measho;Kanwar, Jagat Rakesh;Tikoo, Akshay;Chauhan, Ashok
病原性病毒已经发展了一种分子防御武器库，通过抵消称为RNA干扰（RNAi）的宿主抗病毒系统来维持生存。细胞RNAi除了通过microRNA调节基因表达外，还可作为抵御外来入侵核酸的屏障。RNAi在生物物种中是保守的，包括植物，动物和无脊椎动物。反过来，病毒也进化出了可以抵消宿主这种抗病毒防御的机制。最近对哺乳动物病毒表现出RNA沉默抑制因子（RSS）活性的研究进一步推进了我们对RNAi在宿主-病毒相互作用方面的理解。病毒蛋白和非编码RNA可以通过不同的机制抑制RNAi（miRNA/siRNA）途径。具有dsRNA结合区和GW/WG基序的哺乳动物病毒似乎具有赋予RSS活性的高机会。尽管植物和无脊椎动物病毒的RNA干扰系统已经得到了很好的表征，但哺乳动物病毒的RNA干扰系统仍然需要深入研究，以提供支持其RNAi消融特性的具体证据。在这篇评论中提出的信息与任何前瞻性的研究应该有助于预测和识别RSS活性赋予新的病毒蛋白，可能是设计新的抗病毒治疗的潜在目标。
Pathogenic viruses have developed a molecular defense arsenal for their survival by counteracting the host anti-viral system known as RNA interference (RNAi). Cellular RNAi, in addition to regulating gene expression through microRNAs, also serves as a barrier against invasive foreign nucleic acids. RNAi is conserved across the biological species, including plants, animals and invertebrates. Viruses in turn, have evolved mechanisms that can counteract this anti-viral defense of the host. Recent studies of mammalian viruses exhibiting RNA silencing suppressor (RSS) activity have further advanced our understanding of RNAi in terms of host-virus interactions. Viral proteins and non-coding viral RNAs can inhibit the RNAi (miRNA/siRNA) pathway through different mechanisms. Mammalian viruses having dsRNA-binding regions and GW/WG motifs appear to have a high chance of conferring RSS activity. Although, RSSs of plant and invertebrate viruses have been well characterized, mammalian viral RSSs still need in-depth investigations to present the concrete evidences supporting their RNAi ablation characteristics. The information presented in this review together with any perspective research should help to predict and identify the RSS activity-endowed new viral proteins that could be the potential targets for designing novel anti-viral therapeutics.
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影响因子：
20.3
作者：
Cheng, Sherman M.;Li, James C. B.;Lau, Allan S. Y.
通讯作者：
Lau, Allan S. Y.
DOI：
10.1073/pnas.89.11.4825
发表时间：
1992-06-01
影响因子：
11.1
作者：
CHANG, HW;WATSON, JC;JACOBS, BL
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作者：
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作者：
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通讯作者：
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影响因子：
3.3
作者：
Ahluwalia JK;Khan SZ;Soni K;Rawat P;Gupta A;Hariharan M;Scaria V;Lalwani M;Pillai B;Mitra D;Brahmachari SK
通讯作者：
Brahmachari SK