Strong links are important, but weak links stabilize them
Strong links are important, but weak links stabilize them
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DOI：
10.1016/j.tibs.2004.05.004
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发表时间：
2004-07-01
影响因子：
13.8
通讯作者：
Csermely, P
中科院分区：
文献类型：
--
作者：
Csermely, P
最近，代谢网络通量的高度不均匀分布已被描述在大肠杆菌中，其定义了包含最重要（和最熟悉）的代谢反应的高通量骨架。这些发现可能会导致更好地理解的最小基因集的组织，并为异速生长的比例定律的一个新的解释。大肠杆菌代谢通量的无标度分布突出了代谢网络和其他网络中薄弱环节的重要性。几个已被证明的例子表明，弱连接可能有一个稳定的各种复杂的系统中的一般作用，此外，提供了新的解释水的作用，在势能景观的蛋白质折叠过程。
Recently, a highly uneven distribution of metabolic network fluxes has been described in Escherichia coli that defines a high-flux backbone containing the most important (and most familiar) metabolic reactions. These findings might lead to a better understanding of the organization of the minimal gene set, and to a novel explanation for the allometric scaling laws. The scale-free distribution of the metabolic fluxes of E coli highlights the importance of weak links in metabolic, and other, networks. Several proven examples show that weak links might have a general role in the stabilization of a variety of complex systems and, in addition, provide novel interpretations of the role of water in the potential energy landscape of the protein-folding process.