Power and coherence of sleep spindle frequency activity following hemispheric stroke
Power and coherence of sleep spindle frequency activity following hemispheric stroke
复制标题
DOI：
10.1093/brain/awf021
复制
发表时间：
2002-02-01
期刊：
影响因子：
14.5
通讯作者：
Achermann, P
中科院分区：
文献类型：
--
作者：
Gottselig, JM;Bassetti, CL;Achermann, P
众所周知，脑干和丘脑结构在调节睡眠-觉醒周期中起着关键作用，但大脑半球参与的程度尚不清楚。为了研究大脑半球在睡眠脑电模式形成中的作用，收集了30例大脑半球卒中所致脑损伤患者和12例住院对照组的整夜多导睡眠图记录。记录在卒中的急性期(小于或等于卒中后10天)、亚慢性期(卒中后11-35天)和慢性期(卒中后60天)。记录双极和参考脑电导数。使用放置在病变对面的参考推导进行标准睡眠阶段评分。睡眠阶段2的功率谱和相干谱是根据双极衍生器的记录计算出来的。在平均光谱中，确定了最高的纺锤形频率峰，并计算了其相对于背景光谱的大小。对视觉评分脑电数据的分析表明，与对照组相比，急性期脑损伤受试者的睡眠效率较低，入睡后觉醒时间增加。在脑损伤受试者和住院对照组之间，快速眼动睡眠阶段和非快速眼动睡眠阶段的持续时间没有显著差异。光谱分析显示，与住院对照组相比，脑损伤受试者的功率谱和相干谱中的纺锤峰大小显著减小，这些峰来自于病变同侧的衍生物。受试者内部跨时间的比较表明，从中风的急性期到慢性期，睡眠纺锤体频率活动的功率和一致性显著增加，这表明可塑性机制允许恢复的可能性。我们的发现提供了新的证据，表明大脑半球在人类产生连贯的睡眠纺锤波中起重要作用，并且它们与先前的经验和理论证据相一致，即皮质丘脑投射调节同步纺锤波的产生。由于纺锤波被认为与睡眠期间阻止感觉输入到大脑皮层有关，因此大脑半球中风后同步纺锤波频率活动的减少可能是观察到的睡眠连续性下降的原因之一。
Brainstem and thalamic structures are known to play a critical role in modulating sleep-wake cycles, but the extent to which the cerebral hemispheres are involved remains unclear. To study the role of the cerebral hemispheres in generating sleep EEG patterns, all-night polysomnographic recordings were collected in subjects with brain damage (n=30) caused by hemispheric stroke and in hospitalized controls (n=12). Recordings were made in the acute (less than or equal to10 days post-stroke), subchronic (11-35 days post-stroke) and chronic (>60 days post-stroke) phases of stroke. Bipolar and referential EEG derivations were recorded. Standard sleep stage scoring was conducted using the referential derivation placed opposite the lesion. Sleep stage 2 power and coherence spectra were calculated based on recordings from bipolar derivations. In the mean spectra, the highest spindle frequency peak was identified and its size was calculated relative to the background spectrum. Analysis of visually scored EEG data indicated that, compared with controls, acute phase brain-damaged subjects had lower sleep efficiency and increased waking after sleep onset. The durations of rapid eye movement and non-rapid eye movement sleep stages did not differ significantly between brain-damaged subjects and hospitalized controls. Spectral analyses revealed that, compared with hospitalized controls, brain-damaged subjects had significantly reduced spindle peak sizes in the power and coherence spectra from derivations ipsilateral to the lesion. Within-subject comparisons across time demonstrated that the power and coherence of sleep spindle frequency activity increased significantly from the acute to the chronic phases of stroke, suggesting that plastic mechanisms allowed the possibility of recovery. Our findings provide novel evidence that the cerebral hemispheres are important in generating coherent sleep spindles in humans, and they are consonant with prior empirical and theoretical evidence that corticothalamic projections modulate the generation of synchronous spindle oscillations. Because spindle oscillations are thought to be involved in blocking sensory input to the cortex during sleep, the decrease in synchronous spindle frequency activity following hemispheric stroke may contribute to the observed reduction in sleep continuity.