Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet
Lactobacillus plantarum OLL2712 Regulates Glucose Metabolism in C57BL/6 Mice Fed a High-Fat Diet
复制标题
DOI：
10.3177/jnsv.59.144
复制
发表时间：
2013-04-01
影响因子：
1.6
通讯作者：
Ikegami, Shuuji
中科院分区：
文献类型：
--
作者：
Sakai, Tohru;Taki, Tomoyo;Ikegami, Shuuji
本研究的目的是确定口服植物乳杆菌 OLL2712 (L. plantarum OLL2712) 对高脂饮食诱导肥胖小鼠的葡萄糖和脂质代谢的影响。给予 10(9) cfu 热灭活植物乳杆菌 OLL2712 12 周的小鼠显示出胰岛素响应后血糖水平显着降低。此外，施用植物乳杆菌 OLL2712 的小鼠脂肪组织中白细胞介素 1β 的 mRNA 表达和非酯化脂肪酸的血清水平显着低于对照小鼠。这些结果表明植物乳杆菌 OLL2712 调节葡萄糖代谢。
The aim of the present study was to determine the effect of oral administration of Lactobacillus plantarum OLL2712 (L. plantarum OLL2712) on glucose and lipid metabolism in mice with high-fat diet-induced obesity Mice that had been administered 10(9) cfu heat-killed L. plantarum OLL2712 for 12 wk showed significant reduction of blood glucose levels in response to insulin. Furthermore, mRNA expression of interleukin-1 beta in adipose tissue and serum levels of nonesterified fatty acids in mice administered L. plantarum OLL2712 were significantly lower than those in control mice. These results indicate that L. plantarum OLL2712 regulates glucose metabolism.