Harvey sarcoma virus genome contains no extensive sequences unrelated to those of other retroviruses except ras.
Harvey sarcoma virus genome contains no extensive sequences unrelated to those of other retroviruses except ras.
复制标题
哈维肉瘤病毒基因组不包含与除 ras 之外的其他逆转录病毒无关的大量序列。
DOI：
10.1128/jvi.62.9.3540-3543.1988
复制
发表时间：
1988
影响因子：
5.4
通讯作者：
Stoler,DL
中科院分区：
文献类型：
--
作者：
Manly,KF;Anderson,GR;Stoler,DL
哈维鼠肉瘤病毒基因组包含两组大鼠衍生的遗传信息与莫洛尼小鼠白血病病毒重组。大鼠序列代表ras癌基因和大鼠VL 30元件。VL 30序列具有几个与逆转录病毒序列相似的离散区域，通过在蛋白质数据库中搜索与来自VL 30区域的预测多肽序列的相似性来检测这些区域。在5'端，最相似的序列是猫肉瘤病毒的序列;在3'端，鼠白血病病毒最相似。一些相似区域也可以通过用病毒DNA序列搜索核酸序列数据库来直接检测。最广泛的区域的相似性是对应于在小鼠白血病病毒的pol基因的核酸内切酶。哈维肉瘤病毒基因组中存在的大部分大鼠衍生序列现在可以完全归因于ras或逆转录病毒或逆转录转座子相关序列。
The Harvey murine sarcoma virus genome contains two rat-derived sets of genetic information recombined with the Moloney mouse leukemia virus. The rat sequences represent a ras oncogene and a rat VL30 element. The VL30 sequences have several discrete regions of similarity with retroviral sequences which were detected by searching a protein database for similarities with predicted polypeptide sequences from the VL30 regions. On the 5' side, the most similar sequences were those of feline sarcoma viruses; on the 3' side, murine leukemia viruses were the most similar. Some of the regions of similarity could also be detected directly by searching a nucleic acid sequence database with the viral DNA sequences. The most extensive region of similarity was that which corresponded to the endonuclease in the pol gene of a murine leukemia virus. The majority of the rat-derived sequences present in the Harvey sarcoma virus genome can now be attributed exclusively to ras or retrovirus- or retrotransposon-related sequences.