Quiescent lymphocytes express intracellular transferrin receptors.
Quiescent lymphocytes express intracellular transferrin receptors.
复制标题
静止淋巴细胞表达细胞内转铁蛋白受体。
DOI：
10.1016/s0006-291x(84)80291-0
复制
发表时间：
1984
影响因子：
3.1
通讯作者：
Hamilton,TA
中科院分区：
文献类型：
--
作者：
Weiel,JE;Hamilton,TA
静止和伴刀豆球蛋白A刺激小鼠脾淋巴细胞的表面和细胞内的血清糖蛋白转铁蛋白结合位点的表达进行了检查。仅在促分裂原刺激的细胞表面上观察到转铁蛋白结合活性。当对两个群体的可溶性洗涤剂提取物进行研究时，显示静止淋巴细胞含有大量非表面暴露的细胞内受体，约占增殖细胞总受体补体的20%。由于表面与细胞内结合位点的比率在有丝分裂原刺激后显著增加，在此过程中转铁蛋白受体表达的调节除了结合位点数量的增加外，还可能涉及其亚细胞分布的实质性改变。
Both quiescent and concanavalin A stimulated murine splenic lymphocytes were examined for the expression of surface and intracellular binding sites for the serum glycoprotein transferrin. Transferrin binding activity was observed on the surface of mitogen stimulated cells only. When soluble detergent extracts of both populations were studied, quiescent lymphocytes were shown to contain a significant pool of non-surface exposed, intracellular receptors which was approximately 20% of the total receptor complement of proliferating cells. Because the ratio of surface to intracellular binding sites was dramatically increased following mitogen stimulation, the regulation of transferrin receptor expression during this process may involve a substantial alteration in its subcellular distribution in addition to the well documented increase in number of binding sites.