Analysis of human papillomavirus 16 variants and risk for cervical cancer in Chinese population
Analysis of human papillomavirus 16 variants and risk for cervical cancer in Chinese population
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人乳头瘤病毒16型变种与中国人群宫颈癌风险分析
DOI：
10.1016/j.virol.2015.11.016
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发表时间：
2016-01-15
期刊：
影响因子：
3.7
通讯作者：
Li, Ni
中科院分区：
文献类型：
--
作者：
Hang, Dong;Yin, Yin;Li, Ni
HPV16是最具致癌性的HPV类型，但只有一小部分HPV16感染会进展为癌症。HPV16型内遗传变异被认为具有不同的致癌性。为了研究HPV16变异在中国女性中的风险意义，对298名宫颈癌患者和85名对照(均为HPV16阳性)进行了病例对照研究。HPV16分离株主要是A变种谱系，A4(以前被称为“亚洲”)亚系的变种很常见。与A1-3相比，A4/亚洲变异与宫颈癌风险显著相关(OR=1.72，95%CI=1.04-2.85)。此外，来自东亚的703例病例和323名对照的荟萃分析证实了这种关联(OR=2.82，95%CI=1.44-5.52)。总之，在HPV16阳性的女性中，A4变异似乎预示着更高的宫颈癌风险，这可能为HPV16变异致癌性差异的遗传基础提供线索。(C)2015 Elsevier Inc.保留所有权利。
HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervical cancer patients and 85 controls (all HPV16-positive). HPV16 isolates were predominantly of the A variant lineage, and variants of A4 (previously named "Asian") sublineage were common. A4/Asian variants were significantly associated with increased risk of cervical cancer compared to A1-3 (OR=1.72, 95% CI=1.04-2.85). Furthermore, a meta-analysis including 703 cases and 323 controls from East Asia confirmed the association (OR=2.82, 95% CI=1.44-5.52). In conclusion, A4 variants appear to predict higher risk of cervical cancer among HPV16-positive women, which may provide clues to the genetic basis of differences in the carcinogenicity of HPV16 variants. (C) 2015 Elsevier Inc. All rights reserved.