Eating in the absence of hunger: A genetic marker for childhood obesity in prepubertal boys?
Eating in the absence of hunger: A genetic marker for childhood obesity in prepubertal boys?
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DOI：
10.1038/oby.2006.16
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发表时间：
2006-01-01
期刊：
影响因子：
6.9
通讯作者：
Stunkard, Albert J.
中科院分区：
文献类型：
--
作者：
Faith, Myles S.;Berkowitz, Robert I.;Stunkard, Albert J.
目的：无饥饿进食（EAH）可能是一种行为特征，肥胖促进基因通过这种行为特征促进正能量平衡。本研究的主要目的是比较出生时肥胖风险高与低的儿童在5岁时的EAH。研究方法和程序：这是一项对宾夕法尼亚大学和费城儿童医院婴儿生长研究注册家庭的观察性调查。根据孕妇孕前体重，在医院实验室对出生时肥胖风险高（N = 28）或低（N = 25）的五岁儿童进行了评估。孩子们在吃了一顿随意的晚餐并报告饱了之后，随意吃了11种零食。家长们报告了家里的零食和他们自己的饮食习惯。采用计算机化仪器对3月龄营养吸吮进行评价。结果：高危男孩EAH（平均+/-标准误差= 326 +/- 66 kJ）是低危男孩EAH（平均+/-标准误差= 151 +/- 39 kJ）的2倍多，p = 0.03。在女孩中，EAH的趋势与父母对女儿在家吃零食的限制增加有关（p = 0.06）。EAH与3个月吸吮行为无关。讨论：促进儿童肥胖的基因可能通过EAH部分发挥其影响，这种影响仅限于出生时有肥胖风险的男孩。基因和家庭环境对该性状的独特影响应在后续研究中加以分解。
Objective: Eating in the absence of hunger (EAH) may be a behavioral trait through which obesity-promoting genes promote positive energy balance. The primary aim of this study was to compare children born at high vs. low risk for obesity with respect to EAH at 5 years of age.Research Methods and Procedures: This was an observational investigation of families enrolled in the University of Pennsylvania and The Children's Hospital of Philadelphia's Infant Growth Study. Five-year-old children born at high (N = 28) or low (N = 25) risk for obesity on the basis of maternal prepregnancy body weight were evaluated at a hospital-based laboratory. Children consumed 11 snack foods ad libitum after consuming an ad libitum dinner and reporting fullness. Parents reported on snack foods at home and their own eating styles. Nutritive sucking at 3 months of age was evaluated by computerized apparatus.Results: EAH in high-risk boys (mean +/- standard error = 326 +/- 66 kJ] was more than twice that of low-risk boys (mean +/- standard error = 151 +/- 39 kJ), p = 0.03. Among girls, there was a trend for EAH to be associated with increased parental limitations on daughter snack food consumption at home (p = 0.06). EAH was unrelated to 3-month sucking behavior.Discussion: Genes that promote childhood obesity may partially exert their influence through EAH, an effect that was limited to boys born at risk for obesity. The unique influences of genes and home environment on this trait should be disaggregated in subsequent studies.