Role of flagellum and motility in pathogenesis of Vibrio vulnificus
Role of flagellum and motility in pathogenesis of Vibrio vulnificus
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DOI：
10.1128/iai.72.8.4905-4910.2004
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发表时间：
2004-08-01
影响因子：
3.1
通讯作者：
Park, SJ
中科院分区：
文献类型：
--
作者：
Lee, JH;Rho, JB;Park, SJ
为研究创伤弧菌鞭毛的致病性，构建了创伤弧菌鞭毛蛋白E缺失突变株，并对其致病性进行了检测。这种非运动突变体粘附INT-407细胞的能力及其在生物膜中的作用降低，其对小鼠的致死性也降低。
To assess the role of the flagellum which was detected by immunoscreening of surface proteins of Vibrio vulnificus, anflgE-deleted mutant was constructed and tested for its pathogenicity. The ability of this nonmotile mutant to adhere to INT-407 cells and its role in biofilm were decreased, as was its lethality to mice.