Reduced white matter integrity in primary open-angle glaucoma: A DTI study using tract-based spatial statistics
Reduced white matter integrity in primary open-angle glaucoma: A DTI study using tract-based spatial statistics
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DOI：
10.1016/j.neurad.2012.04.001
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发表时间：
2013-05-01
影响因子：
3.5
通讯作者：
Wang, Jian
中科院分区：
文献类型：
--
作者：
Lu, Peigang;Shi, Linping;Wang, Jian
背景和目的：本研究旨在映射白色物质的改变在原发性开角型青光眼（POAG）通过应用tract-based空间统计（TBSS）analysis.Methods：扩散张量成像（DTI）数据从MRI脑扫描收集15 POAG患者和15名性别和年龄匹配的非青光眼对照使用西门子Trio 3.0特斯拉扫描仪。对于白质分析，使用FSL软件（http：//www.fmrib.ox.ac.uk/fsl/index.html）处理DTI图像。结果：与非青光眼患者相比，POAG患者枕叶白质FA值明显降低（P <0.05），而对照组与POAG患者枕叶白色FA值无明显差异（P> 0.05）。
Background and purpose: The present study was designed to map the alteration of white matter in primary open-angle glaucoma (POAG) by applying tract-based spatial statistics (TBSS) analysis.Methods: Diffusion tensor imaging (DTI) data from MRI brain scans were collected from 15 POAG patients and 15 gender- and age-matched non-glaucoma controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI images were processed using FSL software (http://www.fmrib.ox.ac.uk/fsl/index.html). Fractional anisotropy (FA) between the POAG and control groups was compared by TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement (TFCE).Results: Compared with non-glaucoma subjects, the occipital white matter in POAG patients had significantly lower FA values (p