Hepatic tissue engineering
Hepatic tissue engineering
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DOI：
10.1016/j.trim.2003.12.005
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发表时间：
2004-04-01
影响因子：
1.5
通讯作者：
Vacanti, JR
中科院分区：
文献类型：
--
作者：
Kulig, KM;Vacanti, JR
暴发性肝功能衰竭（FHF）归因于不断上升的医疗费用，并在美国每年造成许多人死亡。目前唯一的解决办法是器官移植。由于捐赠器官日益短缺，许多需要移植的人仍然在等待名单上。肝脏辅助装置（LAD）用于暂时维持肝功能，并在FHF和移植之间架起桥梁。肝组织工程是减轻对供体器官需求的一个步骤;但必须克服许多挑战，包括支架选择，细胞来源和免疫屏障。生物反应器有助于肝细胞存活，并已证明可维持活细胞数周。通过掺入生长因子和有丝分裂原来帮助实现肝脏替代所需的必要功能，其中许多生长因子和有丝分裂原现在可以结合到聚合物支架上并及时释放。利用微机电系统（MEMs）技术等概念，我们的实验室能够模拟肝脏的天然血管系统，并维持功能和可行的肝细胞。在这个平台、技术和进步的基础上进行扩展和改进，将继续朝着开发功能齐全的可植入肝脏的方向发展。(C)2004 Elsevier B. V.保留所有权利。
Fulminant hepatic failure (FHF) attributes to rising medical cost and accounts for many deaths each year in the United States. Currently, the only solution is organ transplantation. Due to increasing donor organ shortage, many in need of transplantation continue to remain on the waiting list. Liver Assist Devices (LADs) are being used to temporarily sustain liver function and bridge the period between FHF and transplantation. Hepatic Tissue Engineering is a step toward alleviating the need for donor organs; yet many challenges must be overcome including scaffold choice, cell source and immunological barriers. Bioreactors have aided in hepatocyte survival and have proven to sustain viable cells for several weeks. Achieving the necessary functions required for hepatic replacement is aided by the incorporation of growth factors and mitogens many that now can be bound to the polymer scaffold and released in a timely manner. Utilizing concepts such as MicroElectroMechanical systems (MEMs) technology, our laboratory is able to mimic the natural vasculature of the liver and sustain functional and viable hepatocytes. Expanding and improving upon this platform, technology, advancements made will continue toward the development of a fully functioning and implantable liver. (C) 2004 Elsevier B.V. All rights reserved.